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Browsing 02.National Laboratory Astana by Type "Article"
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Talhaoui, Ibtissam; Matkarimov, Bakhyt T.; Tchenio, Thierry; Zharkov, Dmitry O.; Saparbaev, Murat K.
(Free Radical Biology and Medicine, 2017-06-01)
Abstract In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T and C, except for minor DNA base modifications such as methylation which serves for defence against foreign DNA or gene ...
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Matkarimov, B.; Saparbaev, M.
(Biopolymers and Cell. doi: http://dx.doi.org/10.7124/bc.000943, 2017)
Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring ...
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Talhaoui, Ibtissam; Couve, Sophie; Gros, Laurent; Ishchenko, Alexander A.; Matkarimov, Bakhyt; Saparbaev, Murat K.
(Nucleic Acids Research, 2014-04-01)
The human thymine-DNA glycosylase (TDG) initiates
the base excision repair (BER) pathway to remove
spontaneous and induced DNA base damage. It was
first biochemically characterized for its ability to remove
T mispaired ...
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Zutterling, Caroline; Mursalimov, Aibek; alhaoui, Ibtissam; Koshenov, Zhanat; Akishev, Zhiger; Bissenbaev, Amangeldy K.; Mazon, Gerard; Geacintov, Nicolas E.; Gasparutto, Didier; Groisman, Regina; Zharkov, Dmitry O.; Matkarimov, Bakhyt T.; Saparbaev, Murat
(BIOCHEMISTRY, BIOPHYSICS AND MOLECULAR BIOLOGY, 2018-12-15)
DNA repair is essential to counteract damage to DNA induced by
endo- and exogenous factors, to maintain genome stability. However, challenges to
the faithful discrimination between damaged and non-damaged DNA strands ...
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Insepov, Z.; Tynyshtykbayev, Kurbangali B.; Kononenko, Oleg V.; Roshchupkin, Dmitry V.
(Nazarbayev University, NURIS, Institute of Microelectronics Technology and High Purity Materials, 2015)
The effect of SAW on the electrical properties of the few-layer (2-3 layers) graphene is
studied. Under the influence of SAW the appearence of acoustoelectric current IAEC in graphene is observed. The sign and magnitude ...
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Jandosov, Jakpar; Alavijeh, Mo; Sultakhan, Shynggyskhan; Baimenov, Alzhan; Bernardo, Maria; Sakipova, Zuriyadda; Azat, Seytkhan; Lyubchyk, Svitlana; Zhylybayeva, Nurzhamal; Naurzbayeva, Gulmira; Mansurov, Zulkhair; Mikhalovsky, Sergey; Berillo, Dmitriy
(Molecules, 2022)
The use of enterosorbents—materials which can be administered orally and eliminate toxic
substances from the gastrointestinal tract (GIT) by sorption—offers an attractive complementary
protection of humans against acute ...
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Ogay, Vyacheslav; Kumasheva, Venera; Baidosova, Sholpan; Li, Yelena; Shpekov, Azat; Makhambetov, Yerbol; Kaliyev, Assylbek; Zhetpisbayev, Berik; Olzhayev, Farkhad; Ramankulov, Yerlan
(Journal of Biotechnology, 2017-08-30)
In this study, we test a novel hypothesis that treatment of stroke with adipose-derived perivascular stem cells (PSCs) promote sensorimotor recovery after stroke in rats. Rat PSCs were isolated from subcutaneous adipose ...
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Saliev, Timur; Kenessary, D; Kenessary, A; Adilgereiuly, Z; Akzholova, N; Erzhanova, A; Dosmukhametov, A; Syzdykov, D; Masoud, Abdul-Razak
(Ubiquity Press, 2019-11-08)
ir pollution in Kazakhstan is caused by many factors and poses serious threats to public health. Ambient air in the cities of Kazakhstan is polluted due to mining and processing of mineral resources, oil and gas production, ...
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Telegenov, Kuat; Tlegenov, Yedige; Shintemirov, Almas
(IEEE Access, 2015-06-02)
Robotics research and education have gained significant attention in recent years due
to increased development and commercial deployment of industrial and service robots. A majority of researchers working on robot grasping ...
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Insepov, Z.; Bross, A.; Qian, Z.; Norem, J.; Huang, D.; Veitzer, S.; Torun, Y.
(Fermilab, 2008)
This paper presents a rst iteration of a model that attempts to describe all aspects of breakdown in rf cavities and provides some estimates of the parameters and parameter ranges involved, as an aid to producing more ...
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Askarova, Sholpan; Sun, Zhe; Sun, Grace Y.; Meininger, Gerald A.; Lee, James C-M.
(PLOS ONE:Open Access journal, 2013-04-12)
Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease ...
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Zholdybayeva, Elena V.; Kozhahmetova, Saniya; Tarlykov, Pavel; Atavliyeva, Sabina; Mukhtarova, Kymbat; Syzdykov, Tleuli; Khasenov, Ruslan; Shevtsov, Alexsandr; Amirgazin, Asylulan; Daniyarov, Asset; Ramankulov, Yerlan
(Microbiology Resource Announcements, 2021-02-04)
Our aim was to study the nucleotide sequences of 9 previously undescribed strains of B. fragilis collected from patients with intra-abdominal diseases at
city hospitals in Nur-Sultan, Kazakhstan.
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Insepov, Z.; Rest, J.; Hofman, G. L.; Yacout, A.; Norman, G. E.; Starikov, S. A.; Stegailov, V. V.
(Transactions of the American Nuclear Society, 2010)
A key issue for fuel behavior codes is their sensitivity to values of various materials properties, many of which have large uncertainties or have not been measured. Kinetic mesoscale models, such as those developed at ...
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Mektepbayeva, Damel; Alibek, Kenneth; Atinbayeva, N.; Irving, S; Zhaisanbayeva, B; Mussurova, S; Mussakhan, S
(Austin Journal of Cancer and Clinical Research, 2015-08)
Melatonin (N-acetyl-5-methoxytryptamine, MLT) is a naturally occurring
hormone secreted by the pineal gland. Clinical evidence suggests that MLT
may have a possible role in the treatment of cancer, where MLT presents
many ...
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Sergazy, Shynggys; Vetrova, Anastassiya; Orhan, Ilkay Erdogan; Deniz, Fatma Sezer Senol; Kahraman, Ahmet; Zhang, Jian-Ye; Aljofan, Mohamad
(Future science, 2021)
Several plant species of the genera Geranium and Erodium were extracted and screened
against five tumor cell lines for their potential antitumor activities. Out of the tested species, four showed
potential antitumor ...
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Sergazy, Shynggys; Gulyayev, Alexander; Amangeldiyeva, Aidana; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Shulgau, Zarina; Chulenbayeva, Laura; Khassenbekova, Zhanagul; Kushugulova, Almagul; Aljofan, Mohamad
(Frontiers in Pharmacology, 2021-09-20)
The aim of this study is determine the in vitro and in vivo antiradical properties and the cytoprotective activity of Allium nutans L. honey extract. The antiradical properties of the extracts were investigated in rabbit ...
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Taipakova, Sabira; Kuanbay, Aigerim; Saint-Pierre, Christine; Gasparutto, Didier; Baiken, Yeldar; Groisman, Regina; Ishchenko, Alexander A.; Saparbaev, Murat; Bissenbaev, Amangeldy K.
(Frontiers Media, 2020-11-26)
Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor ...
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Stepanenko, Valeriy F.
(J. Radiat. Res. Vol. 47, Suppl. A (2006); http://jrr.jstage.jst.go.jp, 2005-03-09)
The paper is an analytical overview of the main results presented at the 3
rd Dosimetry Workshop in Hiroshima (9–11 of March 2005), where different aspects of the dose reconstruction around the Semipalatinsk nuclear test ...
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Yuan, Guanghui; Zhao, Yan; Jin, Huafeng; Bakenov, Zhumabay
(Ionics. Springer-Verlag Berlin Heidelberg 2016, 2016-04-30)
A sulfur/graphene oxide/multiwalled carbon nanotube
(S/GO/MWNT) composite was synthesized via a simple
ultrasonic mixing method followed by heat treatment. By taking
advantage of this solution-based self-assembly ...
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Cantini, Laura; Kairov, Ulykbek; de Reynies, Aurelien; Barillot, Emmanuel; Radvanyi, Francois; Zinovyev, Andrei
(OXFORD UNIV PRESS, 2019)
Motivation
Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on ...