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Browsing 02.National Laboratory Astana by Author "Yang, Xiaoguang"
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Askarova, Sholpan; Yang, Xiaoguang; Lee, James C-M.
(SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease, 2011-01-21)
An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact ...
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Yang, Xiaoguang; Askarova, Sholpan; Sheng, Wenwen; Chen, JK; Sun, Albert Y.; Sun, Grace Y.; Yao, Gang; Leea, James C-M.
(US National Library of Medicine National Institutes of Health, 2010-09-25)
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, ...
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Yang, Xiaoguang; Askarova, Sholpan; Lee, James C-M.
(Mol Neurobiol, 2010-05-01)
Alzheimer's disease is a chronic neurodegenerative
disorder characterized by neuronal loss, cerebrovascular
inflammation, and accumulation of senile plaques in the
brain parenchyma and cerebral blood vessels. ...
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Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M.
(Neuroscience. Author manuscript; available in PMC, 2012-12-29)
Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...
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Zhu, Donghui; Bungart, BrittaniL; Yang, Xiaoguang; Zhumadilov, Zhaxybay; Lee, James C-M.; Askarova, Sholpan
(Frontiers inNeuroscience, 2015-05-27)
P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the
development and progression ...