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Browsing 02.National Laboratory Astana by Author "Lee, James C-M."

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Amyloid-b peptide on sialyl-LewisX-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface

Askarova, Sholpan; Sun, Zhe; Sun, Grace Y.; Meininger, Gerald A.; Lee, James C-M. (PLOS ONE:Open Access journal, 2013-04-12)

Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease ...
Effects of amyloid beta peptide on neurovascular cells

Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes

Askarova, Sholpan; Yang, Xiaoguang; Lee, James C-M. (SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease, 2011-01-21)

An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact ...
Membrane biophysics and mechanics in Alzheimer's disease

Yang, Xiaoguang; Askarova, Sholpan; Lee, James C-M. (Mol Neurobiol, 2010-05-01)

Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. ...
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells

Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M. (Neuroscience. Author manuscript; available in PMC, 2012-12-29)

Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...
Role of membrane biophysics in Alzheimer’s–related cell pathways

Zhu, Donghui; Bungart, BrittaniL; Yang, Xiaoguang; Zhumadilov, Zhaxybay; Lee, James C-M.; Askarova, Sholpan (Frontiers inNeuroscience, 2015-05-27)

P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the development and progression ...