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Browsing 02.National Laboratory Astana by Issue Date

Browsing 02.National Laboratory Astana by Issue Date

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  • Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes 
    Askarova, Sholpan; Yang, Xiaoguang; Lee, James C-M. (SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease, 2011-01-21)
    An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact ...
  • Behavior and food consumption pattern of the population exposed in 1949–1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan 
    Drozdovitch, Vladimir; Schonfeld, Sara; Akimzhanov, Kuat; Aldyngurov, Daulet; Land, Charles E.; Luckyanov, Nickolas; Mabuchi, Kiyohiko; Potischman, Nancy; J. Schwerin, Michael J.; Semenova, Yulia; Tokaeva, Alma; Zhumadilov, Zhaxybay; Bouville, André; Simon, Steven L. (Radiation and Environmental Biophysics, 2011-03)
    The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation ...
  • The influence of the Lop Nor Nuclear Weapons Test Base to the population of the Republic of Kazakhstan 
    Zhumadilov, Kassym; Ivannikov, Alexander; Zharlyganova, Dinara; Stepanenko, Valeriy; Zhumadilov, Zhaxybay; Apsalikov, Kazbek; Toyoda, Shin; Endo, Satoru; Tanaka, Kenichi; Miyazawa, Chuzou; Okamoto, Tetsuji; Hoshi, Masaharu (Radiation Measurements, 2011-04-01)
    Abstract The method of electron spin resonance (ESR) dosimetry was applied to human tooth enamel to obtain estimates of individual absorbed dose for residents of Makanchi, Urdzhar and Taskesken settlements located near the ...
  • Ion Solid Interaction And Surface Modification At RF Breakdown In High‐Gradient Linacs 
    Insepov, Z.; Norem, J.; Veitzer, S. (American Institute of Physics, 2011-06)
    Ion solid interactions have been shown to be an important new mechanism of unipolar arc formation in high-gradient rf linear accelerators through surface self-sputtering by plasma ions, in addition to an intense surface ...
  • Simulation of ion implantation into nuclear materials and comparison with experiment 
    Insepov, Z.; Yun, D.; Ye, B.; Rest, J.; Starikov, S.; Yacout, A. M. (American Institute of Physics, 2011-06)
    Radiation defects generated in Mo formed by sub-MeV Xe ion implantations were studied by atomistic molecular dynamics based on interatomic potential matched to density functional calculations. The results of the simulations ...
  • ESR dosimetry study for the residents of Kazakhstan exposed to radioactive fallout on 24, August 1956 
    Zhumadilov, K.; Ivannikov, A.; Zharlyganova, D.; Zhumadilov, Zh.; Stepanenko, V.; Abralina, Sh.; Sadvokasova, L.; Zhumadilova, A.; Toyoda, S.; Endo, S.; Okamoto, T.; Hoshi, M. (Radiation Measurements, 2011-09-01)
    Abstract The method of electron spin resonance (ESR) dosimetry has been applied to human tooth enamel in order to obtain individual absorbed doses from the population of settlements within the vicinity of the central axis ...
  • Modeling arcs 
    Insepov, Z.; Norem, J.; Vetizer, S.; Mahalingam, S. (American Institute of Physics, 2011-12)
    Although vacuum arcs were first identified over 110 years ago, they are not yet well understood. We have since developed a model of breakdown and gradient limits that tries to explain, in a self-consistent way: arc triggering, ...
  • Sheath parameters for non-Debye plasmas: Simulations and arc damage 
    Morozov, I. V.; Norman, G. E.; Insepov, Z.; Norem, J. (Physical Review Special Topics-Accelerators and Beams, 2012)
    This paper describes the surface environment of the dense plasma arcs that damage rf accelerators, tokamaks, and other high gradient structures. We simulate the dense, nonideal plasma sheath near a metallic surface using ...
  • Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data 
    Terlikbayeva, Assel; Hermosilla, Sabrina; Galea, Sandro; Schluger, Neil; Yegeubayeva, Saltanat; Abildayev, Tleukhan; Muminov, Talgat; Akiyanova, Farida; Bartkowiak, Laura; Zhumadilov, Zhaxybay; Sharman, Almaz; El-Bassel, Nabila (BMC Infectious Diseases. http://www.biomedcentral.com/1471-2334/12/262, 2012)
    Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well ...
  • Secondary electron yield of emissive materials for large-area micro-channel plate detectors: surface composition and film thickness dependencies 
    Jokela, S. J.; Veryovkin, I. V.; Zinovev, A. V.; Elam, J. W.; Mane, A. U.; Peng, Q.; Insepov, Z. (Physics Procedia, 2012)
    The ongoing development of Atomic Layer Deposition (ALD) enables the use of relatively inexpensive and robust borosilicate micro-channel substrates for use as Micro-Channel Plates (MCPs). The surfaces of the channels in ...
  • Simulation of Ion Irradiation of Nuclear Materials and Comparison with Experiment 
    Insepov, Z.; Kuksin, A.; Rest, J.; Starikov, S.; Yanilkin, A.; Yacout, A. M.; Yun, D. (arXiv preprint arXiv:1203.0327, 2012)
    Radiation defects generated in various nuclear materials such as Mo and CeO2, used as a surrogate material for UO2, formed by sub-MeV Xe and Kr ion implantations were studied via TRIM and MD codes. Calculated results were ...
  • Simulations of Fast X-Ray Detectors Based on Multichannel Plates 
    Adams, B.; Insepov, Z.; Ivanov, V.; Norem, J. (Proceedings of IPAC2012, New Orleans, Louisiana, 2012)
    High-performance detectors with high spatial and time resolutions are required in applications such as imaging of fast processes, time-resolved coherent scattering, and time-resolved X-ray spectroscopy. Recently a new type ...
  • Effects of amyloid beta peptide on neurovascular cells 
    Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)
    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
  • ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses 
    Guli, Xiati; Tokay, Tursonjan; Rohde, Marco; Bender, Roland A.; Kohling, Rudiger; Kirschstein, Timo (Neural Plasticity, 2012-05-08)
    Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels ...
  • PIN71 The Potential Public Health Benefit of Pneumococcal Conjugate Vaccines in Kazakhstan 
    Nurgozhin, T.; Yermekbaeva, B.; Topachevskyi, O. (Value in Health, 2012-11-01)
    To evaluate cost–effectiveness of pneumococcal vaccination with 10-valent pneumococcal non-typeable Haemophilus influenzae protein-D conjugate vaccine (PHiD-CV) compared with 13-valent pneumococcal conjugate vaccine (PCV-13) ...
  • The role of infectious agents in urogenital cancers 
    Alibek, Kenneth; Karatayeva, Nargis; Bekniyazov, Ildar (BioMed Central, 2012-12-03)
    Since the late 1990s, infectious agents have been thought to play a role in the pathogenesis of approximately 15% of cancers. It is now widely accepted that infection of stomach tissue with the bacteria Helicobacter pylori ...
  • Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells 
    Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M. (Neuroscience. Author manuscript; available in PMC, 2012-12-29)
    Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...
  • Childhood cancers: what is a possible role of infectious agents? 
    Alibek, Kenneth; Mussabekova, Assel; Kakpenova, Ainur; Duisembekova, Assem; Baiken, Yeldar; Aituov, Bauyrzhan; Karatayeva, Nargis; Zhussupbekova, Ainur (BMC, 2013)
    The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer ...
  • Modeling vacuum arcs in linac structures 
    Norem, J.; Moretti, A.; Insepov, Z.; Nurkenov, S. (Proceedings of PAC2013, Pasadena, 2013)
    We describe our vacuum arc model, which divides breakdown into four stages: trigger, plasma formation, plasma evolution and surface damage. We have modeled all four stages numerically and find that the properties of surface ...
  • Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes 
    Dmitriev, Petr; Kairov, Ulykbek; Robert, Thomas; Barat, Ana; Lazar, Vladimir; Carnac, Gilles; Laoudj-Chenivesse, Dalila; Vassetzky, Yegor S. (Journal of Cellular and Molecular Medicine, 2013)
    Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral ...