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Просмотр02.National Laboratory Astana по теме "Research Subject Categories::MEDICINE"

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Просмотр02.National Laboratory Astana по теме "Research Subject Categories::MEDICINE"

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  • Effects of amyloid beta peptide on neurovascular cells 
    Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)
    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
  • ENGINEERING CHEMOKINE-BASED CCR5 BLOCKERS TO TACKLE INFECTIOUS AND INFLAMMATORY DISEASES 
    Vangelista, Luca (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    The C-C chemokine receptor type 5, CCR5, is expressed on various cell types and is involved in a large number of pathophysiological conditions. In recent years, CCR5 gained a huge attention, as it was found to play a ...
  • ETIOLOGICAL STRUCTURE OF ACUTE BRONCHIOLITIS IN YOUNG CHILDREN 
    Turdalina, B.R.; Bayesheva, D.A.; Seydullaeva, A.Zh.; Omarova, A.K.; Esimkhanova, G.O.; Zhumabek, P. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Bronchiolitis is most common in children under the age of 9 months in (90% of cases). Every year, 150 million cases of bronchiolitis are recorded in the world, 7-13% of which require inpatient treatment and ...
  • EVALUATION OF CYTOTOXICITY OF ORGANOSILICA NANOPARTICLES 
    Zhaisanbayeva, B. A.; Mun, E. A.; Vorobyev, I. A.; Hortelano, G.; Khutoryanskiy, V. V. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Over the past few decades, nanoparticles have been attracting attention of researches in chemical, biomedical, pharmaceutical sciences, due to their unique physicochemical properties. This includes small size, large ...
  • EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICE/ ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ 
    Mussin (Мусин), Y.A. (Е.А.); Bulanin (Буланин), D.S. (Д.С.); Jeffries (Джеффрис), R.G. (Р.Дж.); Zhumadilov (Жумадилов), Zhaxybay (Ж.Ш.); Olzhayev, F.; Federspiel (Федерспил), W.J. (В.Дж.) (ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ, том XVI, № 4, 2014)
    Основной целью данной работы является получение первичных данных о нагнетательной способности гемопомпы устройства Hemolung и способности обеспечить адекватный уровень газообмена при использовании катетеров уменьшенного ...
  • GALACTOSE-INDUCED SKIN AGING: THE ROLE OF OXIDATIVE STRESS 
    Umbayev, Bauyrzhan; Askarova, Sholpan; Almabayeva, Aigul; Saliev, Timur; Masoud, Abdul-Razak; Bulanin, Denis (Hindawi, 2020-06-17)
    Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable of damaging the skin’s vital components through nonenzymatic glycation, ...
  • GENETIC VARIANTS, METABOLOME, AND GUT MICROBIOME BIOMARKERS FOR OBESITY AND AGING IN RANDOMLY SELECTED KAZAKH INDIVIDUALS 
    Akilzhanova, Ainur; Rakhimova, Saule; Kozhamkulov, Ulan; Kairov, Ulykbek; Kushugulova, Almagul R.; Terwilliger, Joseph; Lee, Joseph (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Objective: Metabolic syndrome (MS) is a cluster of inter-related and heritable metabolic traits, which collectively impart unsurpassed risk for atherosclerotic cardiovascular disease and type 2diabetes. Considerable work ...
  • GENOTYPING OF MYCOBACTERIUM TUBERCULOSIS ISOLATES AMONG RECURRENT CASES OF TUBERCULOSIS IN KAZAKHSTAN 
    Akhmetova, A.; Akilzhanova, A.; Toksanbaeva, B.; Bismilda, V.; Chingissova, L.; Kozhamkulov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Tuberculosis still remains one of the major health problems in Kazakhstan. According to the World Health Organization data (2018), Kazakhstan is on the list of 30 countries with high rates of multidrug ...
  • GUT MICROBIOME ALTERATIONS IN SENIORS SUFFERING FROM ALZHEIMER’S DISEASE 
    Askarova, Sholpan; Kaiyrlykyzy, Aiym; Kozhakhmetov, Samat S.; Nurgaziyev, Madiyar; Kushugulova, Almagul R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: One of the important factors influencing human health and attracting increasing attention of scientists during the last two decades is gut microbiome. It has been demonstrated that the links exist between ...
  • Heart and lungs protection technique for cardiac surgery with cardiopulmonary bypass 
    Pichugin, Vladimir; Melnikov, Nikolay; Olzhayev, F.; Medvedev, Alexander; Jourko, Sergey; Gamzaev, Alishir; Chiginev, Vladimir (Central Asian Journal of Global Health, 2014)
    Cardioplegic cardiac arrest with subsequent ischemic-reperfusion injuries can lead to the development of inflammation of the myocardium, leucocyte activation, and release of cardiac enzymes. Flow reduction to the bronchial ...
  • HEREDITARY DISEASES AND CONGENITAL MALFORMATIONS REGISTRATION AND MONITORING INFORMATION SYSTEM 
    Nazarova, L.; Tolegen, N.; Bayanova, M. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction. Database on hereditary diseases is one of the main tasks of healthcare. Register of hereditary pathology allows to assess accurately the frequency of childbirths with various hereditary diseases and congenital ...
  • IDENTIFICATION OF KAZAKH SPECIFIC GENOMIC VARIANTS USING COMPARATIVE GENOMICS ANALYSIS 
    Molkenov, A.; Daniyarov, A.; Sharip, A.; Seisenova, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: The modern development of high-performance genomic technologies opens up new possibilities for studying the human genome. Large-scale genomic research generates huge amounts of data, the active development ...
  • Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsy 
    Klatte, Katharina; Kirschstein, Timo; Otte, David; Pothmann, Leonie; Muller, Lorenz; Tokay, Tursonjan; Kober, Maria; Uebachs, Mischa; Zimmer, Andreas; Beck, Heinz (Neurobiology of Disease, 2013-08-07)
    The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory ...
  • IMPROVEMENT OF NEUROLOGICAL FUNCTION IN RATS WITH ISCHEMIC STROKE BY ADIPOSEDERIVED PERICYTES 
    Ogay, Vyacheslav; Kumasheva, Venera; Li, Yelena; Mukhlis, Sholpan; Sekenova, Aliya; Olzhayev, Farkhad; Tsoy, Andrey; Umbayev, Baurzhan; Askarova, Sholpan; Shpekov, Azat; Kaliyev, Assylbek; Zhetpisbayev, Berik; Makhambetov, Yerbol; Akshulakov, Serik; Saparov, Arman; Ramankulov, Yerlan (SAGE Publications, 2020-09-04)
    Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation ...
  • Induction of Apoptosis in U937 Cells by Using a Combination of Bortezomib and Low-Intensity Ultrasound 
    Saliev, Timur; Feril Jr., Loreto B.; Ogawa, Koichi; Watanabe, Akiko; Begimbetova, Dinara; Molkenov, Askhat; Alimbetov, Dauren; Tachibana, Katsuro (Medical Science Monitor, 2016-12-22)
    Background: We scrutinized the feasibility of apoptosis induction in blood cancer cells by means of low-intensity ultrasoundand the proteasome inhibitor bortezomib (Velcade). Material/Methods: Human leukemic monocyte ...
  • ISOLATION FROM THE KAZAKH TRADITIONAL FOOD PRODUCTS OF A NEW STRAIN OF LACTIC ACID BACTERIA PRODUCING THE HUMAN PLASMINOGEN RECEPTOR 
    Shaikhin, S.; Abitayeva, G.; Abilhadirov, A.; Dossova, A.; Pirmanova, A.; Tynybaeva, I. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Lactobacillus bacteria are one of the most important groups of the human intestinal microbiota that promote health. Adhesion to host tissues represents a crucial early step in the colonization process of either pathogens ...
  • ISOLATION OF NATURAL REPRESENTATIVES OF CARP LACTOFLORA TO CREATE PATHOGEN CONTROL AGENTS THAT CAN BE ALTERNATIVE TO ANTIBIOTICS 
    Urazova, M.; Zakarya, K.; Sarmurzina, Z.; Bissenova, G.; Abitayeva, G.; Shevtsov, A.; Tekebayeva, Zh.; Tynybayeva, I.; Abzhalelov, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Currently, the microbiome of commercial fish species is being actively studied. In reviews, mainly based on metagenome analysis features and formation of intestinal microflora of various fish species of North America, ...
  • LAUNCH OF Q-SYMPHONY BIOINFORMATICS COMPUTING SYSTEM: A HIGH-PERFORMANCE CLUSTER FOR ANALYSIS OF LARGE-SCALE GENOMIC DATASETS 
    Molkenov, A.; Daniyarov, A.; Sharip, A.; Seisenova, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: One whole human genome, provided by next generation sequencing platforms, in raw format takes 20 to 50 GB. In the course of bioinformatics analysis and data analysis, the data volume increases to 300-500 ...
  • Levels and distribution of self-rated health in the Kazakh population: results from the Kazakhstan household health survey 2012 
    Supiyev, Adil; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Sharman, Almaz; Marmot, Michael; Bobak, Martin (BioMed Central Public Health. http://www.biomedcentral.com/1471-2458/14/768, 2014)
    The high and fluctuating mortality and rising health inequalities in post-Soviet countries have attracted considerable attention. However, there are very few individual-level data on distribution of health outcomes in ...
  • Measures of Reducing the Burden of Health Care Costs by Rational Usage of Laboratory Tests 
    Marchenko, Y.; Akhmetove, R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Every year manufacturers offer new tests, postulating that it will improve the outcomes of treatment. That results that laboratories have to face an increasing workload combined with a reduction of resources. ...