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Browsing 02.National Laboratory Astana by Author "be87a864-63eb-4f51-98c9-f40d4ad0b5dd"

Browsing 02.National Laboratory Astana by Author "be87a864-63eb-4f51-98c9-f40d4ad0b5dd"

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  • Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli 
    Zutterling, Caroline; Mursalimov, Aibek; alhaoui, Ibtissam; Koshenov, Zhanat; Akishev, Zhiger; Bissenbaev, Amangeldy K.; Mazon, Gerard; Geacintov, Nicolas E.; Gasparutto, Didier; Groisman, Regina; Zharkov, Dmitry O.; Matkarimov, Bakhyt T.; Saparbaev​, Murat (BIOCHEMISTRY, BIOPHYSICS AND MOLECULAR BIOLOGY, 2018-12-15)
    DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands ...
  • DNA-HISTONE CROSS-LINKS: FORMATION AND REPAIR 
    Pachva, Manideep C.; Kisselev, Alexei F.; Matkarimov, Bakhyt T.; Saparbaev, Murat; Groisman, Regina (Frontiers Media, 2020-12-21)
    The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the ...
  • The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure 
    Martin, Peter R.; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S.; Groisman, Regina; Matkarimov, Bakhyt T.; Parsons, Jason L.; Elder, Rhoderick H.; Saparbaev, Murat K. (Nature Research, 2017)
    Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei ...
  • Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation 
    Matkarimov, Bakhyt T.; Matta, Elie; Kiribayeva, Assel; Khassenov, Bekbolat; Ishchenko, Alexander A. (Springer Nature, 2020-02-28)
    DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise ...
  • XPC DEFICIENCY INCREASES RISK OF HEMATOLOGIC MALIGNANCIES THROUGH MUTATOR PHENOTYPE AND CHARACTERISTIC MUTATIONAL SIGNATURE 
    Yurchenko, Andrey A.; Padioleau, Ismael; Matkarimov, Bakhyt T.; Soulier, Jean; Sarasin, Alain; Nikolaev, Sergey (Nature Research, 2020-11-17)
    Recent studies demonstrated a dramatically increased risk of leukemia in patients with a rare genetic disorder, Xeroderma Pigmentosum group C (XP-C), characterized by constitutive deficiency of global genome nucleotide ...