NU Research Week - 2018
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Item Open Access De Novo Assembly And Bioinformatics Analysis Of M.Tuberculosis Mdr Strains Sequenced On Next-Generation Sequencing Platform(Nazarbayev University, 2018-10-18) Daniyarov, A.; Kairov, U.; Molkenov, A.; Kozhamkulov, U.; Akhmetova, A.; Akilzhanova, A; Zhumadilov, Zh.Tuberculosis remains one of the major problems in public health (1). During the last 10 years the tuberculosis incidence and mortality rate in Kazakhstan decreased by 2.4 times and 6 times, respectively. Despite the decreasing rate of incidences in Kazakhstan last years, the rate of multidrug-resistant (MDR) forms is increasing.Item Open Access Genotyping Of M. Tuberculosis Clinical Isolates From New Cases Of Tuberculosis In Kazakhstan(Nazarbayev University, 2018-10-18) Akhmetova, А.; Akilzhanova, A.; Assatova, B.; Moldakhmetova, N.; Toksanbaeva, B.; Bismilda, V.; Chingissova, L.; Kozhamkulov, U.Tuberculosis (TB) remains a major health problem in Kazakhstan. Despite of that the rates of TB disease and mortality decreased from 58,5/100000 and 4,1/100000 in 2015 to 52,7/100000 and 3,4/100000 in 2016 respectively, the rate of multidrug-resistant TB (MDR-TB) increased from 12,2/100000 in 2014 to 13,5/100000 in 2015 [1]; MDR strains associated with resistance to the main two first line anti-TB drugs – isoniazid and rifampicin are the most dangerous. 27 countries relate to high MDR-TB burden countries, 15 of them in the European region, including Kazakhstan [2]; Methods of genotyping of M. tuberculosis play important role in TB infection control. There are more than 10 methods of genotyping, MIRU-VNTR is one of the widely used method in the world.