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Browsing by Author "Chao, W. T."

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PI4,5P2 regulates the polarized trafficking of integrins through EXO70 for directional cell migration

Jaguparov, A.; Tursynbay, Y.; Kim, A.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

The polarized delivery of integrin adhesion molecules to the leading edge is required for cell migration and has been linked to cancer cell invasion, cancer aggressiveness, and poor patient outcome (1,2). Thus, regulators ...
PIPK1a regulates RAC1 and akt activation to promote cell migration and proliferation

Merzhakupova, D.; Adilgozhina, G.; Kim, A.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

Rac1 activity is concentrated at the front of migrating cells where it initiates signaling processes necessary for cell migration in normal and pathological situations. The signaling pathways downstream of Rac1 are well ...
PIPK1b regulates E-cadherin endocytosis in polarized breast cancer cells and promotes a switch to a migratory phenotype

Azhunussova, A.; Shayakhmetov, Y.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

The endocytosis, degradation, and recycling of cadherins is crucial for the dynamic regulation of adherens junctions and the control of cell-cell adhesion during tissue formation and in many pathological conditions. In ...
PIPK1b regulates integrin endocytosis for focal adhesion disassembly by modulating the recruitment of the endocytic machinery to focal adhesions

Beisekenova, S.; Ospanova, B.; Kabdullayeva, T.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

Cell migration and tissue invasion during tumor metastasis require the regulated disassembly of focal adhesions, but the underlying mechanisms remain poorly defined. We previously showed that the turnover of focal adhesions ...
SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration

Zhubanchaliyev, A.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

The turnover of focal adhesions is essential for normal cell migration and tumor invasion, but the underlying mechanisms are poorly understood. We have previously shown that the disassembly of focal adhesions occurs by ...