Abstract:
The polarized delivery of integrin adhesion molecules to the leading edge is required
for cell migration and has been linked to cancer cell invasion, cancer aggressiveness, and poor patient
outcome (1,2). Thus, regulators of integrin traffic may represent new molecular targets to inhibit tumor
progression. However, identifying the regulatory networks that control integrin traffic has posed a big
challenge, because, in contrast to the internalization of other cargoes, integrins take diverse routes,
depending on their specific ligand, activation state, type of adhesion structure and cell type assayed.
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