DSpace Repository

Browsing by Author "Askarova, Sholpan"

Browsing by Author "Askarova, Sholpan"

Sort by: Order: Results:

  • Age-realted dementia in Kazahstan: adaptation of the 10/66 dementia research group population -based study protocol 
    Kaiyrlykyzy, A.; Adambekov, Sh.; Alimbetov, D.; Askarova, Sholpan (Nazarbayev University, 2014)
    Background. The prevalence of dementia is increasing worldwide as the population ages and affects 10 % of the population over 65 years old and 40 % of people over the age of 80.[1] In Kazakhstan, as well as in other ...
  • Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats 
    Tokay, T.; Rehberg, M.; Kirschstein, T.; Rohde, M.; Mueller, L.; Askarova, Sholpan; Kohling, R.; Zhumadilov, Z. (Nazarbayev University, 2014)
    The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission in the hippocampus, and cognitive ...
  • Amyloid-b peptide on sialyl-LewisX-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface 
    Askarova, Sholpan; Sun, Zhe; Sun, Grace Y.; Meininger, Gerald A.; Lee, James C-M. (PLOS ONE:Open Access journal, 2013-04-12)
    Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease ...
  • Cell therapeutic approaches for the treatment of experimentally induced liver fibrosis 
    Askarova, Sholpan; Umbayev, B.; Tsoy, A.; Bulanin, D.; Ongarbayeva, N.; Shalakhmetova, T. (Nazarbayev University, 2013)
    The results of our study provide evidence that HT improved animal survival and liver functions by generating an ectopic hepatic mass inside the Peyer’s patches. These observations point to the conclusion that hepatocyte ...
  • Differentiation of mesenchymal stem cells into hepatocytes 
    Ualiyeva, S.; Umbayev, B.; Masoud, A.; Askarova, Sholpan (Nazarbayev University, 2014)
    Acute and chronic liver diseases are common in Kazakhstan and other countries. These diseases are known to cause significant disability and death. In many cases, liver transplantation is the last resort for patients with ...
  • Dysfunction of Cerebral Endothelium in Alzheimer's disease 
    Askarova, Sholpan (2015)
    Alzheimer’s disease is the most common form of dementia in the elderly, which accounts up to 80 % of all cases. •Clinical manifestation of the disease includes cognitive impairments such as attention deficit, spatial ...
  • Effect of azelnidipine on beta-amyloid peptide induced dysfunction of cerebral endothelial cells in vitro 
    Askarova, Sholpan; Tsoy, Andrey; Teng, Tao; Lee, James; Zhumadilov, Zhaxybay (Alzheimer's & Dementia, 2014-07-01)
    There is evidence that the receptor for advanced glycation endproducts (RAGE) is a binding site for amyloid β peptide (Aβ). RAGE is a multiligand cell surface receptor which is normally expressed in brain endothelium and, ...
  • Effects of amyloid beta peptide on neurovascular cells 
    Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)
    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
  • Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting 
    D'Souza, Sonia; Murata, Hironobu; Jose, Moncy V.; Askarova, Sholpan; Yantsen, Yuliya; Andersen, Jill D.; Edington, Collin D.J.; Clafshenkel, William P.; Koepsel, Richard R.; Russell, Alan J. (Biomaterials, 2014-11-01)
    Abstract The field of polymer-based membrane engineering has expanded since we first demonstrated the reaction of N-hydroxysuccinimide ester-terminated polymers with cells and tissues almost two decades ago. One remaining ...
  • Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes 
    Askarova, Sholpan; Yang, Xiaoguang; Lee, James C-M. (SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease, 2011-01-21)
    An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact ...
  • Isolation of primary human hepatocytes from cirrhotic liver 
    Ualiyeva, S.; Umbayev, B.; Donbay, A.; Askarova, Sholpan (Nazarbayev University, 2014)
    Chronic degenerative liver diseases are among most complex social, clinical and epidemiological health problems worldwide. This is due to the steady increase in the incidence and mortality of patients with this pathology. ...
  • Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes 
    Yang, Xiaoguang; Askarova, Sholpan; Sheng, Wenwen; Chen, JK; Sun, Albert Y.; Sun, Grace Y.; Yao, Gang; Leea, James C-M. (US National Library of Medicine National Institutes of Health, 2010-09-25)
    Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, ...
  • Membrane biophysics and mechanics in Alzheimer's disease 
    Yang, Xiaoguang; Askarova, Sholpan; Lee, James C-M. (Mol Neurobiol, 2010-05-01)
    Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. ...
  • Polymer coating enhances affinity of bone marrow-derived MSCS to bone 
    Yantsen, Y.; Askarova, Sholpan; Adambekov, S.; Murata, H.; Andersen, J.; D’Souza, S.; Edington, C.; Koepsel, R.; Russell, A. (Nazarbayev University, 2013)
    The polymer coated cells were shown to be stably attached to bone fragments for at least 2 hours, confirming the bone targeting potential of the polymer. Our next step will be to test this approach in rat model of osteoporosis ...
  • Rage targeted strategies for Alzheimer`s Amyloid B peptide include blood brain barrier dysfunctions 
    Askarova, Sholpan; Tsoy, A.; Lee, J.C-M. (Nazarbayev University, 2013)
    This study demonstrated that Aβ binding to RAGE at the CECs and astrocytes surface is required for NADPH oxidase complex assembling, resulting in subsequent ROS generation and phosphorylation of cPLA2α. Therefore, understanding ...
  • Red blood cell ghosts as promising drug carriers to target wound infections 
    Berikkhanova, Kulzhan; Omarbaev, Rustam; Gulyayev, Alexandr; Shulgau, Zarina; Ibrasheva, Dilbar; Adilgozhina, Gulsim; Sergazy, Shynggys; Zhumadilov, Zhaxybay; Askarova, Sholpan (Medical Engineering & Physics, 2016-09-01)
    Abstract Autologous red blood cell ghosts (RBC ghosts) can carry cytokines to the sites of inflammation. The targeting moiety of the RBC ghosts is associated with the nature of purulent inflammation, where the erythrocytes ...
  • Research on the bio-distribution of interferon gamma-containing pharmacocytes 
    Ibrasheva, D.; Idrissova, D.; Umbayev, B.; Masoud, A.; Askarova, Sholpan (Nazarbayev University, 2014)
    Viral hepatitis B and C- is a widespread infectious disease of the liver and is a potential threat to human life. Treatment of HCV and HBV requires prolonged (parenteral or oral) administration of antiviral and ...
  • Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells 
    Askarova, Sholpan; Yang, Xiaoguang; Sheng, Wenwen; Sun, Grace Y.; Lee, James C-M. (Neuroscience. Author manuscript; available in PMC, 2012-12-29)
    Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers ...
  • Role of membrane biophysics in Alzheimer’s–related cell pathways 
    Zhu, Donghui; Bungart, BrittaniL; Yang, Xiaoguang; Zhumadilov, Zhaxybay; Lee, James C-M.; Askarova, Sholpan (Frontiers inNeuroscience, 2015-05-27)
    P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the development and progression ...
  • Role of ros in ab42-mediated activation of cerebral endothelial cells 
    Tsoy, Andrey; Shalakhmetova, Tamara; Umbayev, Bauyrzhan; Askarova, Sholpan (Alzheimer's & Dementia, 2014-07-01)
    There is evidence that the deposition of amyloid-beta peptide (Aβ) in brain parenchyma and brain vessels is the main cause of neuronal dysfunction in Alzheimer's disease (AD). Aβ exhibits multiple cytotoxic effects to ...