Jaguparov, A.; Tursynbay, Y.; Kim, A.; Chao, W. T.; Kunz, J.(Nazarbayev University, 2014)
The polarized delivery of integrin adhesion molecules to the leading edge is required
for cell migration and has been linked to cancer cell invasion, cancer aggressiveness, and poor patient
outcome (1,2). Thus, regulators ...
Merzhakupova, D.; Adilgozhina, G.; Kim, A.; Chao, W. T.; Kunz, J.(Nazarbayev University, 2014)
Rac1 activity is concentrated at the front of migrating cells where it initiates signaling
processes necessary for cell migration in normal and pathological situations. The signaling pathways
downstream of Rac1 are well ...
The endocytosis, degradation, and recycling of cadherins is crucial for the dynamic
regulation of adherens junctions and the control of cell-cell adhesion during tissue formation and in
many pathological conditions. In ...
Cell migration and tissue invasion during tumor metastasis require the regulated
disassembly of focal adhesions, but the underlying mechanisms remain poorly defined. We previously
showed that the turnover of focal adhesions ...
Zhubanchaliyev, A.; Chao, W. T.; Kunz, J.(Nazarbayev University, 2014)
The turnover of focal adhesions is essential for normal cell migration and tumor
invasion, but the underlying mechanisms are poorly understood. We have previously shown that the
disassembly of focal adhesions occurs by ...