NU Research Week - 2018

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Browsing NU Research Week - 2018 by Subject "Tuberculosis (TB)"

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    Genotyping Of M. Tuberculosis Clinical Isolates From New Cases Of Tuberculosis In Kazakhstan
    (Nazarbayev University, 2018-10-18) Akhmetova, А.; Akilzhanova, A.; Assatova, B.; Moldakhmetova, N.; Toksanbaeva, B.; Bismilda, V.; Chingissova, L.; Kozhamkulov, U.
    Tuberculosis (TB) remains a major health problem in Kazakhstan. Despite of that the rates of TB disease and mortality decreased from 58,5/100000 and 4,1/100000 in 2015 to 52,7/100000 and 3,4/100000 in 2016 respectively, the rate of multidrug-resistant TB (MDR-TB) increased from 12,2/100000 in 2014 to 13,5/100000 in 2015 [1]; MDR strains associated with resistance to the main two first line anti-TB drugs – isoniazid and rifampicin are the most dangerous. 27 countries relate to high MDR-TB burden countries, 15 of them in the European region, including Kazakhstan [2]; Methods of genotyping of M. tuberculosis play important role in TB infection control. There are more than 10 methods of genotyping, MIRU-VNTR is one of the widely used method in the world.
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    De Novo Assembly And Bioinformatics Analysis Of M.Tuberculosis Mdr Strains Sequenced On Next-Generation Sequencing Platform
    (Nazarbayev University, 2018-10-18) Daniyarov, A.; Kairov, U.; Molkenov, A.; Kozhamkulov, U.; Akhmetova, A.; Akilzhanova, A; Zhumadilov, Zh.
    Tuberculosis remains one of the major problems in public health (1). During the last 10 years the tuberculosis incidence and mortality rate in Kazakhstan decreased by 2.4 times and 6 times, respectively. Despite the decreasing rate of incidences in Kazakhstan last years, the rate of multidrug-resistant (MDR) forms is increasing.
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    Whole genome sequencing of m. Tuberculosis strains in kazakhstan reveal genomic variants in genes coding pe/ppe protein family specific for mdr/xdr isolates
    (Nazarbayev University, 2018-10-18) Kozhamkulov, U.; Kairov, U.; Molkenov, A.; Steins, M.; Akhmetova, А.; Akilzhanova, A
    Worldwide in 2016, around 10.4 million people were diagnosed with TB among which 1.7 million died [1]. Despite the progress in decreasing the global incidence of drug-susceptible TB, multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the past decade led to decreased efficiency of chemotherapy. However, the rate of drug-resistant TB increases annually, especially multidrug-resistant TB (MDR TB) [1].