Adiponectin play a significant role in the regulation of type 2 diabetes, obesity,
atherosclerosis, non-alcoholic fatty liver disease and neurodegenerative disorders. Evidence
suggests that adiponectin may be an independent risk factor for all-cause dementia and
Alzheimer's disease (AD) and the level of adiponectin in plasma reflects its level in cerebrospinal
fluid (CSF). Studies demonstrated that elevated adiponectin level in blood was associated with
an increased risk of dementia and AD in women and indicates that the sex dimorphism with
regard to adiponectin levels association with Alzheimer's disease was clearly observed