Browsing by Author "Ayazbekova, Akbota"

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    ANALYSIS OF PERIPHERAL BLOOD AND MUCOSAL EOSINOPHILS IN CHILDREN WITH CHRONIC INFLAMMATORY BOWEL DISEASES
    (Nazarbayev University School of Medicine, 2024) Ayazbekova, Akbota
    Inflammatory bowel diseases (IBDs) comprises Crohn’s disease (CD) and Ulcerative colitis (UC), both of which pathogenesis is still under research. There were several studies investigating the role of eosinophil cell activity in the peripheral blood as well as gastrointestinal mucosa in adults, but there has been limited study in the pediatric population. This study aims to assess eosinophil activity in peripheral blood and mucosa, and also assess the correlation in clinical and pathological aspects. The study recruits 96 patients diagnosed with IBDs during the period from January 1, 2018 till December 31, 2022. Patients' eosinophil counts were compared at the first presentation. From selected patients 27 were diagnosed with CD and 69 were diagnosed with UC. Patient’s mean age was 12.4 and 13.1 years, with male to female ratio of 1.25 and 1.3, respectively. Patients groups divided by PBE median to ‘low’ and ‘high’ group, showed statistical difference in mucosal eosinophils (p-value < 0.05). However, groups divided by clinical and inflammatory parameters did not show statistically significant differences (p-value > 0.05). Overall, the study concludes that there is a correlation between eosinophil count in peripheral blood and colonic mucosa in IBDs diagnosed pediatric patients.