ANALYSIS OF PERIPHERAL BLOOD AND MUCOSAL EOSINOPHILS IN CHILDREN WITH CHRONIC INFLAMMATORY BOWEL DISEASES
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Date
2024
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Nazarbayev University School of Medicine
Abstract
Inflammatory bowel diseases (IBDs) comprises Crohn’s disease (CD) and Ulcerative colitis
(UC), both of which pathogenesis is still under research. There were several studies
investigating the role of eosinophil cell activity in the peripheral blood as well as gastrointestinal
mucosa in adults, but there has been limited study in the pediatric population. This study aims to
assess eosinophil activity in peripheral blood and mucosa, and also assess the correlation in
clinical and pathological aspects. The study recruits 96 patients diagnosed with IBDs during the
period from January 1, 2018 till December 31, 2022. Patients' eosinophil counts were compared
at the first presentation. From selected patients 27 were diagnosed with CD and 69 were
diagnosed with UC. Patient’s mean age was 12.4 and 13.1 years, with male to female ratio of
1.25 and 1.3, respectively. Patients groups divided by PBE median to ‘low’ and ‘high’ group,
showed statistical difference in mucosal eosinophils (p-value < 0.05). However, groups divided
by clinical and inflammatory parameters did not show statistically significant differences (p-value
> 0.05). Overall, the study concludes that there is a correlation between eosinophil count in
peripheral blood and colonic mucosa in IBDs diagnosed pediatric patients.
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Keywords
Type of access: Gated, Inflammatory Bowel Diseases, Crohn’s disease, Ulcerative colitis, eosinophil, peripheral eosinophilia, mucosal eosinophil count.
Citation
Ayazbekova, A. (2024). Analysis of Peripheral Blood and Mucosal Eosinophils in Children with Chronic Inflammatory Bowel Diseases. Nazarbayev University School of Medicine