NU Research Week: abstracts

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Browsing NU Research Week: abstracts by Author "Adilbayeva, A."

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    Genetic homongeneity and major histocompatibility complex haplotyping of white mice
    (Nazarbayev University, 2014) Sydykova, K.; Sadykov, M.; Zhailauova, A.; Adilbayeva, A.; Myngbay, A.; Adarichev, V. A.
    Inbred murine strains are generated to insure genetic homogeneity and uniqueness and define immune characteristics, like major histocompatibility complex (MHC) haplotype, of the experimental model. Maintaining of the perfect inbred stock leads to increased level of homozygosity and sometimes encounters a problem of inbreeding depression and consequently deviation from strict inbreeding protocol. Our goals are (i) study genetic homogeneity of mice in the colony, and (ii) haplotyping of H-2 complex (MHC in mice) in this strain.
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    New arthritic pannus-specific protein promotes fibroblast motility and polarization
    (Nazarbayev University, 2014) Adilbayeva, A.; Myngbay, A.; Adarichev, V. A.
    Rheumatoid arthritis (RA) is chronic inflammatory disease characterized by the development of hypercellular pannus tissue in the affected joints of patients. Pannus invasiveness and activation correlates with stronger tissue destruction and worse clinical prognosis. Using murine arthritis model, we recently discovered that synovial concentration of Collagen Triple Helix Repeat-containing 1 (CTHRC1) message and protein is directly correlated with arthritis severity. In carcinogenesis, overexpression of CTHRC1 is associated with enhanced metastatic potential of solid tumors and increased cell motility. Our goal is to investigate the mechanism of synovial cell motility and invasiveness and the role of non-canonical WNT signaling in pannus development.
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    New serum biomarker for rheumatoid arthritis
    (Nazarbayev University, 2014) Myngbay, A.; Adilbayeva, A.; Adarichev, V. A.
    Development of hypercellular invasive pannus tissue within synovial joints is a hallmark of Rheumatoid Arthritis (RA). Pannus produces proteases that damage bone and cartilage. Non-invasive monitoring of pannus activity is important for clinical assessment of patients as well as for control of the efficacy of therapeutic interventions. Available biomarkers are not satisfactory in terms of pannus specificity and sensitivity for monitoring local inflammation and bone erosion. Our goal is collecting clinical samples of synovial fluid and plasma from patients with RA and/or osteoarthritis (OA) to study the role of WNT signaling in pannus formation and developing set of serum biomarkers to monitor pannus activity.
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    Protective effect of peptide vaccination in murine infection with influenza virus
    (Nazarbayev University, 2014) Myngbay, A.; Adilbayeva, A.; Sadykov, M.; Zhailauova, A.; Adarichev, V. A.; Alibek, K.
    Vaccination is a major tool to protect people from seasonal infections of different strains of influenza virus that presently infects millions of individuals worldwide. Virus genome is highly polymorphic, and universal vaccine that protects against permanently changing virus is still under development. Despite notable differences between humans and rodents in the disease course, immunobiology and clinical evaluations, murine infectious models remain one of the major tools to test approaches for influenza vaccine development.