NU Research Week - I

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Browsing NU Research Week - I by Author "Abilova, Zh."

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    Creating prerequisites of personalized approach in the diagnosis and treatment of tuberculosis, based on whole genome-sequencing of M.tuberculosis
    (Nazarbayev University, 2013) Molkenov, A.; Abilmazhinova, A.; Akhmetova, A.; Chingisova, L.; Bismilda, V.; Yerezhepov, D.; Kozhamkulov, U.; Abilova, Zh.; Askapuli, A.; Zhabagin, M.; Kairov, U.; Rahimova, S.; Zhumadilov, Zh.; Akilzhanova, A.
    The next generation sequencing technology provides a tool to obtain genetic data from clinically isolates M.tuberculosis. Using it we can clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance, which will pave the personalized approach in the diagnosis and treatment of TB.
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    Genetic architecture of Kazakh population
    (Nazarbayev University, 2013) Kairov, U.; Molkenov, A.; Zhabagin, M.; Askapuli, A.; Abilmazhinova, A.; Akhmetova, A.; Yerezhepov, D.; Abilova, Zh.; Rahimova, S.; Zhumadilov, Zh.; Akilzhanova, A.
    The aim of the project is to define genetic architecture of Kazakh population by sequencing and analyzing whole exomes and whole genomes of Kazakhs living in different regions of Kazakhstan
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    Mapping of eco-social and genetic factors of susceptibility of tuberculosis among the population of the Rebuplic of Kazakhstan
    (Nazarbayev University, 2013) Akhmetova, A.; Rakhimova, S.; Kairov, U.; Abilova, Zh.; Askapuli, A.; Zhabagin, M.; Yerezhepov, D.; Abilmazhinova, A.; Molkenov, A.; Akilzhanova, A.
    In this study combined design was used, which included: 1) Case-control study; 2) Molecular epidemiological study; and 3) Study of human genetic susceptibility to tuberculosis.This work is the first case-control study in Kazakhstan where complex factors of TB risk and their effects are estimated. The study confirmed the role of main risk factors of tuberculosis development in Kazakhstan: young age, single relationship status, living in rent apartment, smoking, diabetes and migration.