Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology
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Browsing Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology by Author "Ahn, Saeyoung"
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Item Open Access Bonghan Ducts as Possible Pathways for Cancer Metastasis(Journal of Acupuncture and Meridian Studies, 2009-04-01) Yoo, Jung Sun; Kim, Hong Bae; Ogay, Vyacheslav; Lee, Byung-Cheon; Ahn, Saeyoung; Soh, Kwang-supObjective: The present study has been designed to find a possible new route for the metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique of trypan blue staining. Materials and Methods: Tumor tissues were grown in the skin of nude mice after subcutaneous inoculation with human lung cancer cells. Trypan blue was recently identified as a dye with specificity for Bonghan ducts (BHDs) and not other tissues, such as blood or lymph vessels or nerves. Results: We demonstrate that the trypan blue staining technique allows the first visualization of BHDs which are connected to tumor tissues.