Bonghan Ducts as Possible Pathways for Cancer Metastasis
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Date
2009-04-01
Authors
Yoo, Jung Sun
Kim, Hong Bae
Ogay, Vyacheslav
Lee, Byung-Cheon
Ahn, Saeyoung
Soh, Kwang-sup
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Acupuncture and Meridian Studies
Abstract
Objective: The present study has been designed to find a possible new route for the
metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique
of trypan blue staining.
Materials and Methods: Tumor tissues were grown in the skin of nude mice after subcutaneous
inoculation with human lung cancer cells. Trypan blue was recently identified
as a dye with specificity for Bonghan ducts (BHDs) and not other tissues, such as
blood or lymph vessels or nerves.
Results: We demonstrate that the trypan blue staining technique allows the first
visualization of BHDs which are connected to tumor tissues.
Description
Keywords
Bonghan duct, cancer, metastasis, trypan blue, Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology