Abstract:
The data on seroprevalence of anti-SARS-CoV-2 antibodies in Kazakhstani population
are non-existent, but are needed for planning of public health interventions targeted to COVID-19
containment. The aim of the study was to estimate the seropositivity of SARS-CoV-2 infection in the
Kazakhstani population from 2020 to 2021. We relied on the data obtained from the results from “IN
VITRO” laboratories of enzyme-linked immunosorbent assays for class G immunoglobulins (IgG) and
class M (IgM) to SARS-CoV-2. The association of COVID-19 seropositivity was assessed in relation
to age, gender, and region of residence. Additionally, we related the monitoring of longitudinal
seropositivity with COVID-19 statistics obtained from Our World in Data. The total numbers of
tests were 68,732 for SARS-CoV-2 IgM and 85,346 for IgG, of which 22% and 63% were positive,
respectively. The highest rates of positive anti-SARS-CoV-2 IgM results were seen during July/August
2020. The rate of IgM seropositivity was the lowest on 25 October 2020 (2%). The lowest daily rate of
anti-SARS-CoV-2 IgG was 17% (13 December 2020), while the peak of IgG seropositivity was seen on
6 June 2021 (84%). A longitudinal serological study should be envisaged to facilitate understanding
of the dynamics of the epidemiological situation and to forecast future scenarios.