Dysfunction of Cerebral Endothelium in Alzheimer's disease

Abstract

Alzheimer’s disease is the most common form of dementia in the elderly, which accounts up to 80 % of all cases. •Clinical manifestation of the disease includes cognitive impairments such as attention deficit, spatial disorientation, speech disorders, and progressive loss of memory. •In the late stage of Alzheimer's, people generally lose the ability to communicate coherently, experience a decline in physical abilities and require total assistance with personal care. •Those with Alzheimer's live an average of eight years after their symptoms become noticeable to others, but survival can range from four to 20 years, depending on age and other health conditions.--