PERIOSTIN EXPRESSION IN MB49 CELL LINE

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dc.contributor.authorSharyktybay, Aiganym
dc.date.accessioned2024-10-07T09:59:41Z
dc.date.available2024-10-07T09:59:41Z
dc.date.issued2024
dc.description.abstractPeriostin is a secreted matricellular protein known to be imbalanced in many pathological conditions, such as tissue repair, fibrosis, inflammation, tumorigenesis, and metastasis. It is often associated with advanced stages of cancer and poor outcomes. Its upregulation in different cancers and ability to develop chemoresistance in cancer tissues suggest its usage as a prognostic biomarker and curing target for prostate, breast, colorectal, pancreatic, gastric, and lung carcinoma. However, there are controversial studies regarding periostin in bladder cancers. The downrate of periostin was an indicator of high-grade bladder cancers, whereas other bladder cancer cell lines showed upregulation of periostin. The current study determined that periostin is expressed in the MB49 mouse bladder cancer cell line and suggested that further research focusing on the effect of periostin upregulation and knockdown on the tumor growth in the MB49 cell line will help cure bladder cancer by targeting periostin in the future.
dc.identifier.citationSharyktybay, A. (2024). Periostin Expression in MB49 Cell Line. Nazarbayev University School of Medicine
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/8271
dc.language.isoen
dc.publisherNazarbayev University School of Medicine
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.subjectType of access: Restricted
dc.subjectPeriostin
dc.titlePERIOSTIN EXPRESSION IN MB49 CELL LINE
dc.typeBachelor`s Capstone project

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