Reverse the Resistance to PARP Inhibitors
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Date
2017-02-17
Authors
Kim, Yevgeniy
Kim, Aleksei
Sharip, Ainur
Sharip, Aigul
Jiang, Juhong
Yang, Qing
Xie, Yingqiu
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Biological Sciences
Abstract
One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment.
Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. This paper describes several molecular mechanisms of PARPi resistance which were reported most recently, and summarizes some strategies to reverse this type of drug resistance.
Description
Keywords
PARP, PARP inhibitor, drug resistance, DNA repair, Research Subject Categories::NATURAL SCIENCES::Biology
Citation
Kim Yevgeniy et al.(>6), 2017(February 17), Reverse the Resistance to PARP Inhibitors, International Journal of Biological Sciences, vol.13, pp.98-208