Biomarkers and signaling pathways of colorectal cancer stem cells

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dc.contributor.authorAbetov, Danysh
dc.contributor.authorMustapova, Zhanar
dc.contributor.authorSaliev, Timur
dc.contributor.authorBulanin, Denis
dc.date.accessioned2017-01-12T09:07:12Z
dc.date.available2017-01-12T09:07:12Z
dc.date.issued2015-03-01
dc.description.abstractThe progression of colorectal cancer is commonly characterized by accumulation of genetic or epigenetic abnormalities, altering regulation of gene expression as well as normal protein structures and functions. Nonetheless, there are some questions that remain to be elucidated, such as the origin of cancer cells and populations of cells initiating and propagating tumor development. Currently, there are two rival theories describing the process of carcinogenesis. One is the stochastic model, arguing that any cell is capable of initiating and triggering the development of cancer. Meanwhile, the cancer stem cell model hypothesizes that only a small fraction of stem cells possesses cancer-promoting properties. Typically, colorectal cancer stem cells (CSCs) share the same molecular signaling profiles with normal stem cells or embryonic stem cells, such as Wnt, Notch, TGF-β, and Hedgehog. Nevertheless, CSCs differ from normal stem cells and the bulk of tumor cells in their tumorigenic potential and susceptibility to chemotherapeutic drugs. This may be a possible explanation of the high percentage of cancer recurrence in patients who underwent chemotherapeutic treatment and surgery. This review article focuses on the colorectal cancer stem cell biomarkers and the role of upregulated signaling pathways implicated in the initiation and progression of colorectal cancer.ru_RU
dc.identifier.citationAbetov, D., Mustapova, Z., Saliev, T., & Bulanin, D. (2015). Biomarkers and signaling pathways of colorectal cancer stem cells. Tumor Biology, 36(3), 1339-1353. DOI: 10.1007/s13277-015-3198-4ru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2252
dc.language.isoenru_RU
dc.publisherTumor Biologyru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectbiomarkersru_RU
dc.subjectcarcinogenesisru_RU
dc.subjectcolorectal cancerru_RU
dc.subjectsignaling pathwaysru_RU
dc.subjectstem cellsru_RU
dc.titleBiomarkers and signaling pathways of colorectal cancer stem cellsru_RU
dc.typeArticleru_RU

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