Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis

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dc.contributor.authorCatanzaro, R.
dc.contributor.authorZerbinati, N.
dc.contributor.authorSolimene, U.
dc.contributor.authorCelep, G.
dc.contributor.authorMarotta, F.
dc.contributor.authorKushugulova, A.
dc.contributor.authorMilazzo, M.
dc.contributor.authorTomella, C.
dc.contributor.authorBertuccelli, G.
dc.contributor.authorZhumadilov, Z.
dc.date.accessioned2016-02-19T03:22:51Z
dc.date.available2016-02-19T03:22:51Z
dc.date.issued2013
dc.description.abstractThe aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21CIPl1WAF1, GADD153 genes and downregulated the c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.ru_RU
dc.identifier.citationDOI: 10.5582/ddt.2013.v7.5.196ru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1283
dc.language.isoenru_RU
dc.publisherDrug Discoveries & Therapeutics. DOI: 10.5582/ddt.2013.v7.5.196ru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectantimutagenic effectru_RU
dc.subjectcell cycleru_RU
dc.subjectapoptosisru_RU
dc.subjectcelergenru_RU
dc.subjectmarine compoundru_RU
dc.subjectResearch Subject Categories::MEDICINEru_RU
dc.titleEffect of Celergen, a marine derivative, on in vitro hepatocarcinogenesisru_RU
dc.typeArticleru_RU

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