Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development

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dc.contributor.authorWoldeyesus, Masresha T.
dc.contributor.authorBritsch, Stefan
dc.contributor.authorRiethmacher, Dieter
dc.contributor.authorXu, Lan
dc.contributor.authorSonnenberg-Riethmacher, Eva
dc.contributor.authorAbou-Rebyeh, Faikah
dc.contributor.authorHarvey, Richard
dc.contributor.authorCaroni, Pico
dc.contributor.authorBirchmeier, Carmen
dc.date.accessioned2016-03-30T03:18:01Z
dc.date.available2016-03-30T03:18:01Z
dc.date.issued1999
dc.description.abstractThe ErbB2 tyrosine kinase functions as coreceptor for the neuregulin receptors ErbB3 and ErbB4 and can participate in signaling of EGF receptor (ErbB1), interleukin receptor gp130, and G-protein coupled receptors. ErbB2−/− mice die at midgestation because of heart malformation. Here, we report a genetic rescue of their heart development by myocardial expression of erbB2 cDNA that allows survival of the mutants to birth. In rescued erbB2 mutants, Schwann cells are lacking. Motoneurons form and can project to muscle, but nerves are poorly fasciculated and disorganized. Neuromuscular junctions form, as reflected in clustering of AChR and postsynaptic expression of the genes encoding the a-AChR, AChE, e-AChR, and the RI subunit of the cAMP protein kinase. However, a severe loss of motoneurons on cervical and lumbar, but not on thoracic levels occurs. Our results define the roles of Schwann cells during motoneuron and synapse development, and reveal different survival requirements for distinct motoneuron populationsru_RU
dc.identifier.citationMasresha T. Woldeyesus, Stefan Britsch, Dieter Riethmacher, Lan Xu, Eva Sonnenberg-Riethmacher, Faikah Abou-Rebyeh, Richard Harvey, Pico Caroni, Carmen Birchmeier; 1999; Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development; GENES & DEVELOPMENTru_RU
dc.identifier.issn0890-9369/99
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1350
dc.language.isoenru_RU
dc.publisherCold Spring Harbor Laboratory Pressru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectMotoneuron lossru_RU
dc.subjectneuromuscular synapseru_RU
dc.subjectcoreceptorru_RU
dc.subjectneuregulinru_RU
dc.subjectAChRru_RU
dc.titlePeripheral nervous system defects in erbB2 mutants following genetic rescue of heart developmentru_RU
dc.typeArticleru_RU

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