YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice

Abstract

In chickens, damage activates YAP in supporting cells, enabling hair cell regeneration; in mice, constitutive LATS1/2 activity suppresses this. Deleting LATS or activating YAP variants promotes proliferation even in adult murine utricles.

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Rudolf M.A. et al. (2020). Journal of Neuroscience, 40(20), 3915–3932. DOI: 10.1523/JNEUROSCI.0122-20.2020

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