Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones
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Date
2018-10-04
Authors
Du, Xiaochen
Huang, Jianjun
Nechaev, Anton A.
Yao, Ruwei
Gong, Jing
Van der Eycken, Erik V.
Pereshivko, Olga P.
Peshkov, Vsevolod A.
Journal Title
Journal ISSN
Volume Title
Publisher
Beilstein J. Org. Chem.
Abstract
A series of propargylamides containing an electron-rich benzene ring was prepared through the Ugi reaction of 3,5-dimethoxyaniline with various propiolic acids, aldehydes and isocyanides. Subjecting these adducts to a gold-catalyzed intramolecular alkyne hydroarylation process allowed to efficiently construct the 2-quinolone core bearing a branched substituent on the nitrogen atom...
Description
Keywords
gold catalysis, hydroarylation, Ugi reaction
Citation
Du, X.; Huang, J.; Nechaev, A. A.; Yao, R.; Gong, J.; Van der Eycken, E. V.; Pereshivko, O. P.; Peshkov, V. A. Beilstein J. Org. Chem. 2018, 14, 2572–2579. doi:10.3762/bjoc.14.234