Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Simple item page
dc.contributor.authorMadikyzy Malika
dc.contributor.authorTilegen Meruyert
dc.contributor.authorNazarbek Guldan
dc.contributor.authorMu Chenglin
dc.contributor.authorKutzhanova Aidana
dc.contributor.authorLi Xugang
dc.contributor.authorMa Cuiping
dc.contributor.authorXie Yingqiu
dc.date.accessioned2025-08-27T04:54:29Z
dc.date.available2025-08-27T04:54:29Z
dc.date.issued2022-08-22
dc.description.abstractHonghua ( Carthami flos ) and Xihonghua ( Croci stigma ) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.en
dc.identifier.citationMadikyzy Malika; Tilegen Meruyert; Nazarbek Guldan; Mu Chenglin; Kutzhanova Aidana; Li Xugang; Ma Cuiping; Xie Yingqiu. (2022). Honghua extract mediated potent inhibition of COVID-19 host cell pathways. Scientific Reports. https://doi.org/10.1038/s41598-022-15338-9en
dc.identifier.doi10.1038/s41598-022-15338-9
dc.identifier.urihttps://doi.org/10.1038/s41598-022-15338-9
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/10413
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserveden
dc.source(2022)en
dc.titleHonghua extract mediated potent inhibition of COVID-19 host cell pathwaysen
dc.typearticleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1038_s41598-022-15338-9.pdf
Size:
3.88 MB
Format:
Adobe Portable Document Format
Download

Collections

Articles