ANTI-INFLAMMATORY, ANTIOXIDANT, AND ANTI-ATHEROSCLEROTIC EFFECTS OF NATURAL SUPPLEMENTS ON PATIENTS WITH FMF-RELATED AA AMYLOIDOSIS: A NON-RANDOMIZED 24-WEEK OPEN-LABEL INTERVENTIONAL STUDY

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dc.contributor.authorRomano, Micol
dc.contributor.authorGarcia-Bournissen, Facundo
dc.contributor.authorPiskin, David
dc.contributor.authorRodoplu, Ulkumen
dc.contributor.authorPiskin, Lizzy
dc.contributor.authorElzagallaai, Abdelbaset A.
dc.contributor.authorTuncer, Tunc
dc.contributor.authorSezer, Siren
dc.contributor.authorUcuncuoglu, Didar
dc.contributor.authorHonca, Tevfik
dc.contributor.authorPoddighe, Dimitri
dc.contributor.authorYavuz, Izzet
dc.contributor.authorStenvinkel, Peter
dc.contributor.authorYilmaz, Mahmut Ilker
dc.contributor.authorDemirkaya, Erkan
dc.date.accessioned2023-06-26T08:26:36Z
dc.date.available2023-06-26T08:26:36Z
dc.date.issued2022
dc.description.abstractWe aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were >18 years and had proteinuria (>3500 mg/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu/Znsuperoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21–66)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis.en_US
dc.identifier.citationRomano, M., Garcia-Bournissen, F., Piskin, D., Rodoplu, U., Piskin, L., Elzagallaai, A. A., Tuncer, T., Sezer, S., Üçüncüoğlu, D., Honca, T., Poddighe, D., Yavuz, I., Stenvinkel, P., Yilmaz, M. I., & Demirkaya, E. (2022). Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study. Life, 12(6), 896. https://doi.org/10.3390/life12060896en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/7250
dc.language.isoenen_US
dc.publisherlifeen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectType of access: Open Accessen_US
dc.subjectfamilial Mediterranean feveren_US
dc.subjectAA amyloidosisen_US
dc.subjectnatural supplementationen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectoxidative stressen_US
dc.subjectinflammationen_US
dc.titleANTI-INFLAMMATORY, ANTIOXIDANT, AND ANTI-ATHEROSCLEROTIC EFFECTS OF NATURAL SUPPLEMENTS ON PATIENTS WITH FMF-RELATED AA AMYLOIDOSIS: A NON-RANDOMIZED 24-WEEK OPEN-LABEL INTERVENTIONAL STUDYen_US
dc.typeArticleen_US
workflow.import.sourcescience

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