Composite Cryogel with Polyelectrolyte Complexes for Growth Factor Delivery

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dc.contributor.authorSultankulov, B.
dc.contributor.authorBerillo, D.
dc.contributor.authorKauanova, S.
dc.contributor.authorMikhalovsky, S.
dc.contributor.authorMikhalovska, L.
dc.contributor.authorSaparov, A.
dc.date.accessioned2020-05-04T10:44:44Z
dc.date.available2020-05-04T10:44:44Z
dc.date.issued2019
dc.description.abstractMacroporous scaffolds composed of chitosan (CHI), hydroxyapatite (HA), heparin (Hep), and polyvinyl alcohol (PVA) were prepared with a glutaraldehyde (GA) cross-linker by cryogelation. Addition of PVA to the reaction mixture slowed down the formation of a polyelectrolyte complex (PEC) between CHI and Hep, which allowed more thorough mixing, and resulted in the development of the homogeneous matrix structure. Freezing of the CHI-HA-GA and PVA-Hep-GA mixture led to the formation of a non-stoichiometric PEC between oppositely charged groups of CHI and Hep, which caused further efficient immobilization of bone morphogenic protein 2 (BMP-2) possible due to electrostatic interactions. It was shown that the obtained cryogel matrix released BMP-2 and supported the differentiation of rat bone marrow mesenchymal stem cells (rat BMSCs) into the osteogenic lineage. Rat BMSCs attached to cryogel loaded with BMP-2 and expressed osteocalcin in vitro. Obtained composite cryogel with PEC may have high potential for bone regeneration and tissue engineering applications.en_US
dc.identifier.citationSultankulov, B., Berillo, D., Kauanova, S., Mikhalovsky, S., Mikhalovska, L., & Saparov, A. (2019). Composite Cryogel with Polyelectrolyte Complexes for Growth Factor Delivery. Pharmaceutics, 11(12), 650. https://doi.org/10.3390/pharmaceutics11120650en_US
dc.identifier.issn1999-4923
dc.identifier.other10.3390/pharmaceutics11120650
dc.identifier.urihttps://www.mdpi.com/1999-4923/11/12/650
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics11120650
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4596
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesPharmaceutics;
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectbiomaterialsen_US
dc.subjectcryogelen_US
dc.subjectdrug deliveryen_US
dc.subjectgrowth factorsen_US
dc.subjecttissue engineeringen_US
dc.subjectbone regenerationen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleComposite Cryogel with Polyelectrolyte Complexes for Growth Factor Deliveryen_US
dc.typeArticleen_US
workflow.import.sourcescience

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