Pressure-volume Relationship in the Stress-echocardiography Laboratory: Does (Left Ventricular End-diastolic) Size Matter?

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dc.contributor.authorBombardini, Tonino
dc.contributor.authorMulieri, Louis A.
dc.contributor.authorSalvadori, Stefano
dc.contributor.authorCostantino, Marco Fabio
dc.contributor.authorScali, Maria Chiara
dc.contributor.authorMarzilli, Mario
dc.contributor.authorPicano, Eugenio
dc.creatorTonino, Bombardini
dc.date.accessioned2017-12-22T08:08:01Z
dc.date.available2017-12-22T08:08:01Z
dc.date.issued2017-02-01
dc.description.abstractAbstract Introduction and objectivesThe variation between rest and peak stress end-systolic pressure-volume relation is an afterload-independent index of left ventricular contractility. Whether and to what extent it depends on end-diastolic volume remains unclear. The aim of this study was to assess the dependence of the delta rest-stress end-systolic pressure-volume relation on end-diastolic volume in patients with negative stress echo and all ranges of resting left ventricular function. MethodsWe analyzed interpretable data obtained in 891 patients (593 men, age 63 ± 12 years) with ejection fraction 47% ± 12%: 338 were normal or near-normal or hypertensive; 229 patients had coronary artery disease; and 324 patients had ischemic or nonischemic dilated cardiomyopathy. They were studied with exercise (n = 172), dipyridamole (n = 482) or dobutamine (n = 237) stress echocardiography. The end-systolic pressure-volume relation was evaluated at rest and peak stress from raw measurement of systolic arterial pressure by cuff sphygmomanometer and end-systolic volume by biplane Simpson rule 2-dimensional echocardiography. ResultsAbsolute values of delta rest-stress end-systolic pressure-volume relation were higher for exercise and dobutamine than for dipyridamole. In the overall population, an inverse relationship between end-systolic pressure-volume relation and end-diastolic volume was present at rest (r2 = 0.69, P < .001) and peak stress (r2 = 0.56, P < .001), but was absent if the delta rest-stress end-systolic pressure-volume relation was considered (r2 = 0.13). ConclusionsLeft ventricular end-diastolic volume does not affect the rest-stress changes in end-systolic pressure-volume relation in either normal or abnormal left ventricles during physical or pharmacological stress.en_US
dc.identifierDOI:10.1016/j.rec.2016.04.047
dc.identifier.citationTonino Bombardini, Louis A. Mulieri, Stefano Salvadori, Marco Fabio Costantino, Maria Chiara Scali, Mario Marzilli, Eugenio Picano, Pressure-volume Relationship in the Stress-echocardiography Laboratory: Does (Left Ventricular End-diastolic) Size Matter?, In Revista Española de Cardiología (English Edition), Volume 70, Issue 2, 2017, Pages 96-104en_US
dc.identifier.issn18855857
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1885585716301384
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3048
dc.language.isoenen_US
dc.publisherRevista Española de Cardiología (English Edition)en_US
dc.relation.ispartofRevista Española de Cardiología (English Edition)
dc.rights.license© 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.
dc.subjectStress echocardiographyen_US
dc.subjectPhysiologyen_US
dc.subjectDiastoleen_US
dc.subjectContractilityen_US
dc.titlePressure-volume Relationship in the Stress-echocardiography Laboratory: Does (Left Ventricular End-diastolic) Size Matter?en_US
dc.typeArticleen_US
elsevier.aggregationtypeJournal
elsevier.coverdate2017-02-01
elsevier.coverdisplaydateFebruary 2017
elsevier.endingpage104
elsevier.identifier.doi10.1016/j.rec.2016.04.047
elsevier.identifier.eid1-s2.0-S1885585716301384
elsevier.identifier.piiS1885-5857(16)30138-4
elsevier.issue.identifier2
elsevier.openaccess0
elsevier.openaccessarticlefalse
elsevier.openarchivearticlefalse
elsevier.startingpage96
elsevier.teaserThe variation between rest and peak stress end-systolic pressure-volume relation is an afterload-independent index of left ventricular contractility. Whether and to what extent it depends on end-diastolic...
elsevier.volume70
workflow.import.sourcescience

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