CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application

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dc.contributor.authorWinkler, B.Sophia
dc.contributor.authorOltmer, Franziska
dc.contributor.authorRichter, Julia
dc.contributor.authorBischof, Joachim
dc.contributor.authorXu, Pengfei
dc.contributor.authorBurster, Timo
dc.contributor.authorLeithäuser, Frank
dc.contributor.authorKnippschild, Uwe
dc.date.accessioned2018-08-20T09:10:02Z
dc.date.available2018-08-20T09:10:02Z
dc.date.issued2015-02-20
dc.description.abstractThe prognosis of lymphoid neoplasms has improved considerably during the last decades. However, treatment response for some lymphoid neoplasms is still poor, indicating the need for new therapeutic approaches. One promising new strategy is the inhibition of kinases regulating key signal transduction pathways, which are of central importance in tumorigenesis. Kinases of the CK1 family may represent an attractive drug target since CK1 expression and/or activity are associated with the pathogenesis of malignant diseases. Over the last years efforts were taken to develop highly potent and selective CK1-specific inhibitor compounds and their therapeutic potential has now to be proved in pre-clinical trials. Therefore, we analyzed expression and mutational status of CK1δ in several cell lines representing established lymphoma entities, and also measured the mRNA expression level in primary lymphoma tissue as well as in non-neoplastic blood cells. For a selection of lymphoma cell lines we furthermore determined CK1δ kinase activity and demonstrated therapeutic potential of CK1-specific inhibitors as a putative therapeutic option in the treatment of lymphoid neoplasmsen_US
dc.identifier.citationWinkler, B. S., Oltmer, F., Richter, J., Bischof, J., Xu, P., Burster, T., L00eithäuser, F. & Knippschild, U. 2015. CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application. Frontiers in Cell and Developmental Biology. 3, p. 9en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3390
dc.language.isoenen_US
dc.publisherFrontiers in Cell and Developmental Biologyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectCK1en_US
dc.subjectlymphomaen_US
dc.subjecttherapyen_US
dc.subjectinhibitoren_US
dc.subjectmutationanalysisen_US
dc.subjectcellcycleen_US
dc.titleCK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic applicationen_US
dc.typeArticleen_US
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