Tuberculosis diagnosis using immunodominant, secreted antigens of Mycobacterium tuberculosis

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dc.contributor.authorBekmurzayeva, Aliya
dc.contributor.authorSypabekova, Marzhan
dc.contributor.authorKanayeva, Damira
dc.creatorAliya, Bekmurzayeva
dc.date.accessioned2017-12-13T04:19:34Z
dc.date.available2017-12-13T04:19:34Z
dc.date.issued2013-07-01
dc.description.abstractSummary Tuberculosis (TB) remains a major public health concern in most low-income countries. Hence, rapid and sensitive TB diagnostics play an important role in detecting and preventing the disease. In addition to established diagnostic methods, several new approaches have been reported. Some techniques are simple but time-consuming, while others require complex instrumentation. One prominent and readily available approach is to detect proteins that Mycobacterium tuberculosis secretes, such as Mpt64, the 6-kDa early secreted antigenic target (Esat6), the 10-kDa culture filtrate protein (Cfp10), and the antigen 85 (Ag85) complex. Although their functions are not fully understood, a growing body of molecular evidence implicates them in M. tuberculosis virulence. Currently these biomarkers are either being used or investigated for use in skin patch tests, biosensor analyses, and immunochromatographic, immunohistochemical, polymerase chain reaction-based, and enzyme-linked immunosorbent assays. This review provides a comprehensive discussion of the roles these immunodominant antigens play in M. tuberculosis pathogenesis and compares diagnostic methods based on the detection of these proteins with more established tests for TB.en_US
dc.identifierDOI:10.1016/j.tube.2013.03.003
dc.identifier.citationAliya Bekmurzayeva, Marzhan Sypabekova, Damira Kanayeva, Tuberculosis diagnosis using immunodominant, secreted antigens of Mycobacterium tuberculosis, In Tuberculosis, Volume 93, Issue 4, 2013, Pages 381-388en_US
dc.identifier.issn14729792
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1472979213000826
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2858
dc.language.isoenen_US
dc.publisherTuberculosisen_US
dc.relation.ispartofTuberculosis
dc.rightsOpen Access - the content is available to the general publicen_US
dc.rights.licenseCopyright © 2013 Elsevier Ltd. All rights reserved.
dc.subjectTuberculosis diagnosisen_US
dc.subjectMpt64en_US
dc.subjectEsat6en_US
dc.subjectCfp10en_US
dc.subjectAg85en_US
dc.subjectBiosensoren_US
dc.titleTuberculosis diagnosis using immunodominant, secreted antigens of Mycobacterium tuberculosisen_US
dc.typeBook chapteren_US
elsevier.aggregationtypeJournal
elsevier.coverdate2013-07-01
elsevier.coverdisplaydateJuly 2013
elsevier.endingpage388
elsevier.identifier.doi10.1016/j.tube.2013.03.003
elsevier.identifier.eid1-s2.0-S1472979213000826
elsevier.identifier.piiS1472-9792(13)00082-6
elsevier.identifier.pubmedid23602700
elsevier.identifier.scopusid84878945554
elsevier.issue.identifier4
elsevier.openaccess0
elsevier.openaccessarticlefalse
elsevier.openarchivearticlefalse
elsevier.startingpage381
elsevier.teaserTuberculosis (TB) remains a major public health concern in most low-income countries. Hence, rapid and sensitive TB diagnostics play an important role in detecting and preventing the disease. In addition...
elsevier.volume93
workflow.import.sourcescience

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