NETWORK PHARMACOLOGY WITH EXPERIMENTAL INVESTIGATION OF THE MECHANISMS OF RHIZOMA POLYGONATI AGAINST PROSTATE CANCER WITH ADDITIONAL HERBZYMATIC ACTIVITY

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dc.contributor.authorKazybay, Bexultan
dc.contributor.authorSun, Qinglei
dc.contributor.authorDukenbayev, Kanat
dc.contributor.authorNurkesh, Ayan Amantaiuly
dc.contributor.authorXu, Na
dc.contributor.authorKutzhanova, Aidana
dc.contributor.authorRazbekova, Madina
dc.contributor.authorKabylda, Anar
dc.contributor.authorYang, Qing
dc.contributor.authorWang, Qian
dc.contributor.authorMa, Cuiping
dc.contributor.authorXie, Yingqiu
dc.date.accessioned2023-02-13T11:36:14Z
dc.date.available2023-02-13T11:36:14Z
dc.date.issued2022
dc.description.abstractA combination therapy of Rhizoma Polygonati (RP) with goji (Lycium chinense) has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase. For network pharmacology analysis, RP-induced PI3K-AKT pathways are essential for both benign prostatic hyperplasia and prostate cancer, and the RP/goji combination induces potent pathways which include androgen and estrogen response, kinase regulation, apoptosis, and prostate cancer singling. In addition, the experimental investigation showed that the prostate cancer cells are sensitive to RP extract for inhibiting colony formation. Finally, the natural compound baicalein found in RP ingredients showed a linked activity of top-ranked signaling targets of kinases including MAPK, AKT, and EGFR by the database of cMAP and HERB. Thus, both the nanozyme and ingredients might contribute to the RP in anti-prostate cancer which can be enhanced by goji extract. The proposed nanoscale RP extract might be of significance in developing novel anti-prostate cancer agents by combining goji compositions and targeted therapy compounds.en_US
dc.identifier.citationSakaguchi, N., Kaumbekova, S., Itano, R., Torkmahalleh, M. A., Shah, D., & Umezawa, M. (2022b). Changes in the Secondary Structure and Assembly of Proteins on Fluoride Ceramic (CeF3) Nanoparticle Surfaces. ACS Applied Bio Materials. https://doi.org/10.1021/acsabm.2c00239en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/6952
dc.language.isoenen_US
dc.publisherACS Applied Bio Materialsen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectType of access: Open Accessen_US
dc.subjectPharmacologyen_US
dc.subjectRhizoma Polygonatien_US
dc.subjectProstate Canceren_US
dc.titleNETWORK PHARMACOLOGY WITH EXPERIMENTAL INVESTIGATION OF THE MECHANISMS OF RHIZOMA POLYGONATI AGAINST PROSTATE CANCER WITH ADDITIONAL HERBZYMATIC ACTIVITYen_US
dc.typeArticleen_US
workflow.import.sourcescience

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