Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms

Simple item page
dc.contributor.authorBarteneva, Natasha S.
dc.contributor.authorBaiken, Yeldar
dc.contributor.authorFasler-Kan, Elizaveta
dc.contributor.authorAlibek, Kenneth
dc.contributor.authorWang, Sheng
dc.contributor.authorMaltsev, Natalia
dc.contributor.authorPonomarev, Eugene D.
dc.contributor.authorSautbayeva, Zarina
dc.contributor.authorKauanova, Sholpan
dc.contributor.authorMoore, Anna
dc.contributor.authorBeglinger, Christoph
dc.contributor.authorVorobjev, Ivan A.
dc.creatorNatasha S., Barteneva
dc.date.accessioned2018-01-04T09:57:31Z
dc.date.available2018-01-04T09:57:31Z
dc.date.issued2017-12-01
dc.description.abstractAbstract Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicles). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations. This review focuses on research evaluating the role of EV production in gastrointestinal (GI) cancer development in conjunction with GI microbiota and inflammatory diseases. We also discuss recent studies on the promising role of EVs and their content as biomarkers for early diagnosis of GI cancers.The bMVs have also been implicated in the pathogenesis of GI chronic inflammatory diseases, however, possible role of bMVs in tumorigenesis remains underestimated. We propose that EVs from eukaryotic cells as well as from different microbial, fungi, parasitic species and edible plants in GI tract act as mediators of intracellular and inter-species communication, particularly facilitating tumor cell survival and multi-drug resistance.In conclusion, we suggest that matching sequences from EV proteomes (available from public databases) with known protein sequences of microbiome gut bacteria will be useful in identification of antigen mimicry between evolutionary conservative protein sequences. Using this approach we identified Bacteroides spp. pseudokinase with activation loop and homology to PDGFRα, providing a proof-of-concept strategy. We speculate that existence of microbial pseudokinase that ‘mimics’ PDGFRα may be related to PDGFRα and Bacteroides spp. roles in colorectal carcinogenesis that require further investigation.en_US
dc.identifierDOI:10.1016/j.bbcan.2017.06.005
dc.identifier.citationNatasha S. Barteneva, Yeldar Baiken, Elizaveta Fasler-Kan, Kenneth Alibek, Sheng Wang, Natalia Maltsev, Eugene D. Ponomarev, Zarina Sautbayeva, Sholpan Kauanova, Anna Moore, Christoph Beglinger, Ivan A. Vorobjev, Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms, In Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1868, Issue 2, 2017, Pages 372-393en_US
dc.identifier.issn0304419X
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0304419X17300975
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3100
dc.language.isoenen_US
dc.publisherBiochimica et Biophysica Acta (BBA) - Reviews on Canceren_US
dc.relation.ispartofBiochimica et Biophysica Acta (BBA) - Reviews on Cancer
dc.rights.license© 2017 The Authors. Published by Elsevier B.V.
dc.subjectExtracellular vesiclesen_US
dc.subjectExosomesen_US
dc.subjectInter-species communicationen_US
dc.subjectGastrointestinal canceren_US
dc.subjectBacteroides fragilisen_US
dc.subjectPseudokinaseen_US
dc.titleExtracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdomsen_US
dc.typeArticleen_US
elsevier.aggregationtypeJournal
elsevier.coverdate2017-12-01
elsevier.coverdisplaydateDecember 2017
elsevier.endingpage393
elsevier.identifier.doi10.1016/j.bbcan.2017.06.005
elsevier.identifier.eid1-s2.0-S0304419X17300975
elsevier.identifier.piiS0304-419X(17)30097-5
elsevier.identifier.scopusid85026814252
elsevier.issue.identifier2
elsevier.openaccess1
elsevier.openaccessarticletrue
elsevier.openaccessuserlicensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
elsevier.openarchivearticlefalse
elsevier.startingpage372
elsevier.teaserExtracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicles). They are small vesicles with phospholipid membrane carrying proteins,...
elsevier.volume1868
workflow.import.sourcescience

Files

Collections

Articles