Immune phenotypes predict survival in patients with glioblastoma multiforme

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dc.contributor.authorMostafa, Haouraa
dc.contributor.authorPala, Andrej
dc.contributor.authorHögel, Josef
dc.contributor.authorHlavac, Michal
dc.contributor.authorDietrich, Elvira
dc.contributor.authorWesthoff, M. Andrew
dc.contributor.authorNonnenmacher, Lisa
dc.contributor.authorBurster, Timo
dc.contributor.authorGeorgieff, Michael
dc.contributor.authorWirtz, C. Rainer
dc.contributor.authorSchneider, E. Marion
dc.date.accessioned2018-08-20T09:10:18Z
dc.date.available2018-08-20T09:10:18Z
dc.date.issued2016-09-01
dc.description.abstractBackground: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patients with GBM. Methods: Immune phenotypes and plasma biomarkers of GBM patients were determined at the time of diagnosis using flow cytometry and ELISA, respectively. Results: Using descriptive statistics, we found that immune anomalies were distinct in individual patients. Defined marker profiles proved highly relevant for survival. A remarkable relation between activated NK cells and improved survival in GBM patients was in contrast to increased CD39 and IL-10 in patients with a detrimental course and very short survival. Recursive partitioning analysis (RPA) and Cox proportional hazards models substantiated the relevance of absolute numbers of CD8 cells and low numbers of CD39 cells for better survival. Conclusions: Defined alterations of the immune system may guide the course of disease in patients with GBM and may be prognostically valuable for longitudinal studies or can be applied for immune intervention.en_US
dc.identifier.citationMostafa, H., Pala, A., Högel, J., Hlavac, M., Dietrich, E., Westhoff, M. A., Nonnenmacher, L., Burster, T., Georgieff, M., Wirtz, C. R. & Schneider, E. M. 2016. Immune phenotypes predict survival in patients with glioblastoma multiforme. Journal of Hematology and Oncology. 9, 1, p. 77en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3391
dc.language.isoenen_US
dc.publisherJournal of Hematology and Oncologyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectGlioblastoma multiformeen_US
dc.subjectCD8+ lymphocytesen_US
dc.subjectNK cellsen_US
dc.subjectCD39-ectonucleotidaseen_US
dc.subjectRecursive partitioning analysisen_US
dc.subjectSurvivalen_US
dc.titleImmune phenotypes predict survival in patients with glioblastoma multiformeen_US
dc.typeArticleen_US
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