DEVELOPMENT OF A PROTOTYPE POINT-OF-CARE LATERAL FLOW ASSAY TEST SYSTEM FOR MEASURING BLOOD OR PLASMA LEVELS OF CTHRC1 PROTEIN, A NEW BIOMARKER FOR THE DIAGNOSIS OF RHEUMATOID ARTHRITIS.

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dc.contributor.authorZholdybay, Aigerim
dc.date.accessioned2024-08-23T06:23:32Z
dc.date.available2024-08-23T06:23:32Z
dc.date.issued2024
dc.description.abstractRheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by proliferative synovitis and inflammatory arthritis accompanied by erosions. RA affects symmetrically peripheral joints multiple times and often leads to disability. Early diagnosis and appropriate treatment are essential for the management of RA. This in turn will help to minimize irreversible changes in synovial joints and to achieve remission or low disease activity. Despite the existing biomarkers, such as rheumatoid factor (RF) and anti-citrullinated antibodies (ACPAs), approximately 20-30% of patients are negative for these markers even with the onset of RA and the development of erosions. Collagen triple helix repeat-containing 1 protein (CTHRC1) serves as a secreted modulator of Wnt signaling, plays a crucial role in joint remodeling regulation, and facilitates cell proliferation and migration. CTHRC1 was previously identified as a highly sensitive and specific blood-based biomarker for RA that can enable the differential diagnosis of patients...
dc.identifier.citationZholdybay, A. (2024). Development of a prototype point-of-care lateral flow assay test system for measuring blood or plasma levels of CTHRC1 protein, a new biomarker for the diagnosis of rheumatoid arthritis. Nazarbayev University School of Medicine
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/8241
dc.language.isoen
dc.publisherNazarbayev University School of Medicine
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.subjectType of access: Gated
dc.titleDEVELOPMENT OF A PROTOTYPE POINT-OF-CARE LATERAL FLOW ASSAY TEST SYSTEM FOR MEASURING BLOOD OR PLASMA LEVELS OF CTHRC1 PROTEIN, A NEW BIOMARKER FOR THE DIAGNOSIS OF RHEUMATOID ARTHRITIS.
dc.typeMaster`s thesis

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