ANALYSIS OF PERIPHERAL BLOOD BASOPHILS IN PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
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Date
2022
Authors
Dossybayeva, Kuanysh
Bexeitov, Yergali
Mukusheva, Zaure
Almukhamedova, Zhaina
Assylbekova, Maykesh
Abdukhakimova, Diyora
Rakhimzhanova, Marzhan
Poddighe, Dimitri
Journal Title
Journal ISSN
Volume Title
Publisher
Diagnostics
Abstract
Basophils are the least abundant circulating leukocytes, and their immunological role has not yet been completely elucidated. There is evidence supporting their immunomodulatory role in several pathological settings; recently, studies in both experimental models and humans suggested that basophil homeostasis may be altered in systemic lupus erythematosus (SLE). Here, we first assessed circulating basophils in children affected with pediatric SLE (pSLE). In this cross-sectional study, circulating basophils were enumerated by fluorescence-based flow cytometry analysis in children affected with pSLE, in addition to children suffering from juvenile idiopathic arthritis (JIA) or non-inflammatory/non-rheumatic conditions. This study included 52 pediatric patients distributed in these three groups. We observed a statistically significant reduction of peripherally circulating basophils in children with pSLE compared to the other two groups of patients. This preliminary study is consistent with the available studies in adult patients with SLE showing a reduced number of circulating basophils. However, further research is needed to draw final conclusions on basophils’ homeostasis in pSLE, in addition to their correlation with the disease activity and concomitant therapies.
Description
Keywords
Type of access: Open Access, basophils, systemic lupus erythematosus, juvenile idiopathic arthritis, eosinophils, children, fluorescence flow cytometry analysis
Citation
Dossybayeva, K., Bexeitov, Y., Mukusheva, Z., Almukhamedova, Z., Assylbekova, M., Abdukhakimova, D., Rakhimzhanova, M., & Poddighe, D. (2022). Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus. Diagnostics, 12(7), 1701. https://doi.org/10.3390/diagnostics12071701