ANTIPROLIFERATIVE AND CYTOTOXIC ACTIVITY OF GERANIACEAE PLANT EXTRACTS AGAINST FIVE TUMOR CELL LINES

Abstract

Several plant species of the genera Geranium and Erodium were extracted and screened against five tumor cell lines for their potential antitumor activities. Out of the tested species, four showed potential antitumor action against all the tumor cells used. Interestingly, they appeared to achieve their antitumor activities by inducing important cellular defense mechanisms called autophagy and apoptosis. The current work is the first to test the antiproliferative potential of these species against different tumor cells.