Deletion of HP1γ in cardiac myocytes afects H4K20me3 levels but does not impact cardiac growth

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dc.contributor.authorEl‑Nachef, Danny
dc.contributor.authorFang, Chen
dc.contributor.authorKajimoto, Hidemi
dc.contributor.authorBrown, Jeremy P.
dc.contributor.authorSingh, Prim B.
dc.contributor.authorMacLellan, W. Robb
dc.date.accessioned2020-03-26T11:12:25Z
dc.date.available2020-03-26T11:12:25Z
dc.date.issued2018-04-18
dc.description.abstractHeterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. Cardiac myocytes (CMs) accumulate heterochromatin during differentiation and demethylation of H3K9me3 inhibits cell cycle gene silencing and cell cycle exit in CMs; however, it is unclear if this process is mediated by HP1s. In this study, we created a conditional CM-specific HP1 gamma (HP1γ) knockout (KO) mouse model and tested whether HP1γ is required for cell cycle gene silencing and cardiac growth....en_US
dc.identifier.citationOyama K., El-Nachef D., Fang C., Kajimoto H., Brown JP., Singh PB., MacLellan WR. (2018) Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth.Epigenetics Chromatin.en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4550
dc.language.isoenen_US
dc.publisherEpigenetics Chromatinen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectcardiac myocytesen_US
dc.subjectcell cycleen_US
dc.subjectconditional knockouten_US
dc.subjectgene expressionen_US
dc.titleDeletion of HP1γ in cardiac myocytes afects H4K20me3 levels but does not impact cardiac growthen_US
dc.typeArticleen_US
workflow.import.sourcescience

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