Establishment of small cell lung cancer cell lines and validation of their growth characteristics

Abstract

Rapidly metastasizing lung cancer is the top killer in the United States and many other countries. In 2014, there were nearly 224 210 new cases of lung cancer and 159 260 predicted mortality from the disease in the US and approximately 44 488 new registered cases of lung cancer in 2012 with 80% mortality and 5 % survival rate within 10 years of diagnosis in the UK. Lung cancer is the most prevalent type of cancer in Kazakhstan accounting for nearly 22.1 % of all cancer cases. Small cell lung cancers (SCLCs) derived from the hormonal cells of the lung and classified as one of the most dedifferentiated cancers representing 10 - 15% of all lung cancers however showing extremely aggressive and rapid dissemination into various parts of the body. In this work we established SCLC cell line and characterised their growth for upcoming research purposes.