ASSOCIATIONS BETWEEN SERUM LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR, CORTICOTROPIN RELEASING HORMONE AND MENTAL DISTRESS IN VITILIGO PATIENTS

Abstract

Vitiligo is clinically characterized by the appearance of non-symptomatic depigmented macules, but the disorder is highly correlated with a wide range of psychiatric disorders and psychological problems. The aim of our study was to investigate serum brain-derived neurotrophic factor (BDNF) and corticotropin releasing hormone (CRH) levels in vitiligo patients and healthy controls in relation to the observed symptoms of depression and anxiety disorders. This study comprised 96 vitiligo patients and 96 healthy controls who flled out the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales. Serum levels of BDNF and CRH were measured using enzyme linked immunosorbent assay (ELISA) technique. There was a signifcant increase of depression and anxiety scores in vitiligo patients as compared with healthy controls (P< 0.05). The serum levels of BDNF were signifcantly lower in vitiligo patients than in healthy individuals (Z= 4.002; P< 0.001), while the serum levels of CRH were markedly higher in cases than those in controls (Z= 3.764; P< 0.001). The signifcant positive correlations between serum CRH levels and GAD-7, PHQ-9 scores were observed. However, the aforementioned psychometric scales did not correlate signifcantly with serum BDNF level. Vitiligo is associated with the depression and is closely linked with lower BDNF levels