Anticancer activity of metformin: a systematic review of the literature

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dc.contributor.authorAljofan, Mohamad
dc.contributor.authorRiethmacher, Dieter
dc.date.accessioned2019-12-11T05:46:07Z
dc.date.available2019-12-11T05:46:07Z
dc.date.issued2019-08
dc.descriptionhttps://www.ncbi.nlm.nih.gov/pubmed/31534778en_US
dc.description.abstractBACKGROUND: The anticancer activity of metformin has been confirmed against several cancer types in vitro and in vivo. However, the underlying mechanisms of metformin in the treatment of cancer are not fully understood. This systematic review aims to discuss the possible anticancer mechanism of action of metformin. METHOD: A search through different databases was conducted, including Medline and EMBASE. RESULTS: A total of 96 articles were identified of which 56 were removed for duplication and 24 were excluded after reviewing the title and abstract. A total of 12 research articles were included that describe different antiproliferative mechanisms that may contribute to the antineoplastic effects of metformin. CONCLUSION: This analysis discussed the potential anticancer activity of metformin and highlighted the importance of AMPK as a potential target for anticancer therapy.en_US
dc.identifier.citationAljofan, M., & Riethmacher, D. (2019). Anticancer activity of metformin: a systematic review of the literature. Future Science OA, 5(8), FSO410. https://doi.org/10.2144/fsoa-2019-0053en_US
dc.identifier.other000490580000002
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4359
dc.language.isoenen_US
dc.publisherFUTURE SCI LTDen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAMPKen_US
dc.subjectanticanceren_US
dc.subjectcanceren_US
dc.subjectmechanism of actionen_US
dc.subjectmetforminen_US
dc.titleAnticancer activity of metformin: a systematic review of the literatureen_US
dc.typeArticleen_US
workflow.import.sourcescience

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