PIPK1a regulates RAC1 and akt activation to promote cell migration and proliferation
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Date
2014
Authors
Merzhakupova, D.
Adilgozhina, G.
Kim, A.
Chao, W. T.
Kunz, J.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
Rac1 activity is concentrated at the front of migrating cells where it initiates signaling
processes necessary for cell migration in normal and pathological situations. The signaling pathways
downstream of Rac1 are well characterized. However, how Rac1 activation is regulated to confer cell
movement is incompletely understood.
Description
Keywords
rac1, cell, osteosarcoma, breast cancer, biochemical, plasma membrane