DYNAMIC CHANGES IN MICROBIOME COMPOSITION FOLLOWING MARE’S MILK INTAKE FOR PREVENTION OF COLLATERAL ANTIBIOTIC EFFECT

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dc.contributor.authorKushugulova, Almagul R.
dc.contributor.authorLöber, Ulrike
dc.contributor.authorAkpanova, Saniya
dc.contributor.authorRysbekov, Kairat
dc.contributor.authorKozhakhmetov, Samat S.
dc.contributor.authorKhassenbekova, Zhanagul R.
dc.contributor.authorEssex, Morgan
dc.contributor.authorNurgozhina, Ayaulym
dc.contributor.authorNurgaziyev, Madiyar
dc.contributor.authorBabenko, Dmitriy
dc.contributor.authorMarko, Lajos
dc.contributor.authorForslund, Sofia K.
dc.date.accessioned2021-09-17T05:35:19Z
dc.date.available2021-09-17T05:35:19Z
dc.date.issued2021-04-21
dc.description.abstractIntroduction: Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High antibiotic usage is especially common in children with developing microbiome. We hypothesized that dry Mare’s milk, which is rich in biologically active substances without containing live bacteria, could be used as a prebiotic in promoting microbial diversity following antibiotic treatment in children. The present pilot study aims to determine the impacts of dry Mare’s milk on the diversity of gut bacterial communities when administered during antibiotic treatment and throughout the subsequent recovery phase. Methods: Six children aged 4 to 5 years and diagnosed with bilateral bronchopneumonia were prescribed cephalosporin antibiotics. During the 60 days of the study, three children consumed dry Mare’s milk whereas the other three did not. Fecal samples were collected daily during antibiotic therapy and every 5 days after antibiotic therapy. Total DNA was isolated and taxonomic composition of gut microbiota was analyzed by 16S rRNA amplicon sequencing. To assess the immune status of the gut, stool samples were analyzed by bead-based multiplex assays. Results: Mare’s milk treatment seems to prevent the bloom of Mollicutes, while preventing the loss of Coriobacteriales. Immunological analysis of the stool reveals an effect of Mare’s milk on local immune parameters under the present conditions.en_US
dc.identifier.citationKushugulova, A., Löber, U., Akpanova, S., Rysbekov, K., Kozhakhmetov, S., Khassenbekova, Z., Essex, M., Nurgozhina, A., Nurgaziyev, M., Babenko, D., Markó, L., & Forslund, S. K. (2021). Dynamic Changes in Microbiome Composition Following Mare’s Milk Intake for Prevention of Collateral Antibiotic Effect. Frontiers in Cellular and Infection Microbiology, 11. https://doi.org/10.3389/fcimb.2021.622735en_US
dc.identifier.issn2235-2988
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fcimb.2021.622735/full
dc.identifier.urihttps://doi.org/10.3389/fcimb.2021.622735
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5819
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofseriesFrontiers in Cellular and Infection Microbiology;11. https://doi.org/10.3389/fcimb.2021.622735
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subject16S rRNA gene sequencingen_US
dc.subjectcollateral antibiotic effecten_US
dc.subjectintestinal immunityen_US
dc.subjectmare’s milken_US
dc.subjectmicrobiomeen_US
dc.subjectType of access: Open Accessen_US
dc.titleDYNAMIC CHANGES IN MICROBIOME COMPOSITION FOLLOWING MARE’S MILK INTAKE FOR PREVENTION OF COLLATERAL ANTIBIOTIC EFFECTen_US
dc.typeArticleen_US
workflow.import.sourcescience

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