Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan
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Date
2016-05-11
Authors
Rakhimova, S.
Kairov, U.
Molkenov, A.
Zhukov, Y.
Omarov, M.
Popova, M.
Zhumadilov, Zh.
Akilzhanova, A.
Journal Title
Journal ISSN
Volume Title
Publisher
National Laboratory Astana, Nazarbayev University 2016
Abstract
Esophageal cancer is the eighth most common cancer in the world and the highest in Eastern Asia. The incidence rate in Kazakhstan is 10.1: 100 000. Esophageal squamous cell carcinoma (ESCC) is the dominant histological type (> 90%) of esophageal cancer cases. Usage of NGS technologies allows determining effective diagnostic markers and therapeutic approaches for to increase the longevity of the patients. The aim of the project is to identify genetic basis of ESCC by performing whole transcriptome sequencing in Kazakhstani patients.
Description
Keywords
esophageal cancer, transcriptome, molecular pathways, up and down-regulated genes
Citation
Rakhimova, S., Kairov, U., Molkenov, A., Zhukov, Y., Omarov, M., Popova, M., Zhumadilov, Zh., Akilzhanova, A. 2016. Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1519.