Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study

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dc.contributor.authorSikhayeva, Nurgul
dc.contributor.authorIskakova, Aisha
dc.contributor.authorSaigi-Morgui, Nuria
dc.contributor.authorZholdybaeva, Elena
dc.contributor.authorEap, Chin-Bin
dc.contributor.authorRamanculov, Erlan
dc.date.accessioned2017-11-16T05:38:02Z
dc.date.available2017-11-16T05:38:02Z
dc.date.issued2017-07-24
dc.description.abstractBackground: We evaluated the associations between single nucleotide polymorphisms and different clinical parameters related to type 2 diabetes mellitus (T2DM), obesity risk, and metabolic syndrome (MS) in a Kazakh cohort. Methods: A total of 1336 subjects, including 408 T2DM patients and 928 control subjects, were recruited from an outpatient clinic and genotyped for 32 polymorphisms previously associated with T2DM and obesity-related phenotypes in other ethnic groups. For association studies, the chi-squared test or Fisher’s exact test for binomial variables were used. Logistic regression was conducted to explore associations between the studied SNPs and the risk of developing T2DM, obesity, and MS, after adjustments for age and sex. Results: After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). In addition, examination of general unmatched T2DM and control cohorts revealed significant associations between T2DM and SNPsrs1799883 (FABP2) and rs9939609 (FTO). Furthermore, polymorphisms in the FTO gene were associated with increased obesity risk, whereas polymorphisms in the FTO and FABP2 genes were also associated with the risk of developing MS in general unmatched cohorts. Conclusion: We confirmed associations between polymorphisms within the SLC30A8, TSPAN8/LGR5, FABP2, and FTO genes and susceptibility to T2DM in a Kazakh cohort, and revealed significant associations with anthropometric and metabolic traits. In particular, FTO and FABP2 gene polymorphisms were significantly associated with susceptibility to MS and obesity in this cohort.ru_RU
dc.identifier.citationSikhayeva Nurgul et al.(>5), 2017(July 24), Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study, BMC Medical Geneticsru_RU
dc.identifier.uriDOI 10.1186/s12881-017-0443-2
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2824
dc.language.isoenru_RU
dc.publisherBMC Medical Geneticsru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectgenetic variantsru_RU
dc.subjectkazakh cohortru_RU
dc.subjectmetabolic syndromeru_RU
dc.subjectObesityru_RU
dc.subjecttype 2 diabetes mellitusru_RU
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biologyru_RU
dc.titleAssociation between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control studyru_RU
dc.typeArticleru_RU

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