CYP1A2 polymorphism does not modulate caffeine's effects on sprint performance or its metabolites during a soccer match simulation

Abstract

The effectiveness of caffeine supplementation on exercise performance varies between individuals. Cytochrome P450 1A2 (CYP1A2) is an important enzyme that controls the primary catabolism of caffeine to paraxanthine, theobromine and theophylline, which are potent adenosine receptor antagonists. The cause of variation in responsiveness to caffeine might be associated with a (C/A) single nucleotide polymorphism of CYP1A2. This study assessed the influence of CYP1A2 polymorphism on caffeine metabolites and sprint performance during a soccer simulation protocol.