PUBLISHER CORRECTION: LABEL-FREE FIBER-OPTIC SPHERICAL TIP BIOSENSOR TO ENABLE PICOMOLAR-LEVEL DETECTION OF CD44 PROTEIN

Abstract

Increased level of CD44 protein in serum is observed in several cancers and is associated with tumor burden and metastasis. Current clinically used detection methods of this protein are time-consuming and use labeled reagents for analysis. Therefore exploring new label-free and fast methods for its quantification including its detection in situ is of importance. This study reports the first optical fiber biosensor for CD44 protein detection, based on a spherical fiber optic tip device. The sensor is easily fabricated from an inexpensive material (single-mode fiber widely used in telecommunication) in a fast and robust manner through a CO2 laser splicer...